张 玮 倪 江 程龙庆 张 辉 王京花 张丽敏 哈尔滨医科大学生理教研室，哈尔滨150086 基础医学与临床 1999 0 19 6


    关键词：γ-氨基丁酸；谷氨酸； 雌二醇； 孕酮； 颗粒细胞 期刊 jcyxylc 0 研究论文 fur -->


    

摘要 本实验采用离体孵育的兔卵巢颗粒细胞，观察四种氨基酸神经递质对颗粒细胞雌二醇和孕酮生成的影响。结果表明，γ-氨基丁酸和谷氨酸能明显刺激颗粒细胞在基础状况下雌二醇的分泌而抑制孕酮的分泌；甘氨酸和天门冬氨酸无此作用。γ-氨基丁酸、甘氨酸和谷氨酸明显促进hCG诱导的颗粒细胞雌二醇的分泌和抑制孕酮的分泌；而天门冬氨酸无此作用。发挥作用的机制可能与腺苷酸环化酶-cAMP系统有关。

Effect of Inhibitory andExcitatory Amino Acid on the Production of

    Estrogen and Progesterone by Granulosa Cells of Rabbits in Vitro

Zhang Wei Ni Jiang Cheng Longqing et al

    (Department of Physiology , Harbin Medical University ,Harbin 150086)

In the present experiment ，theeffects of GABA，Glu，Gly and Asp on the secretion of estradiol(E2)and progesterone (P)by cultured rabbit ovarian granulosa cells in vitro were investigated.The resultsshowed that GABA and Glu could significantly stimulate estradiol and inhibite basalprogesterone secretion.While Gly and Asp had no significant effect.In addition ......