心肌细胞外基质的改变与心力衰弱
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中图分类号：R541 文献标识码：A 文章编号：1001-6352(2000)03-0022-06
Abstract：Cardiacextracellular matrix(ECM) consists of several groups of extracellularmacromolecules.In adult myocardium，the major components of ECM include collagen subtypes，fibronectin，laminin，metalloproteases(MMP)，and tissue inhibitors of metalloproteases(TIMP).As a major component，cardiaccollagen provides alignment to myocardial cells and serves as the skeleton of cardiaccollagen network(CNW)，Which maintains the ventricular chambers in normal structuralarchitecture and function. Chronic congestive heart failure(CHF) ......
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