摘要 目的：探讨Cyclin E和p53的同时表达对预测粘膜下层胃癌预后的作用。方法：用免疫组化法检测48例粘膜下层胃癌中Cyclin E和p53的表达。结果：粘膜下层胃癌中Cyclin E阴性、阳性和强阳性组的p53表达率分别为19%(5/27)、42%(5/12)、89%(8/9)(P<0.01)。同时表达的总发生率为27%(13/48)。同时表达的发生率分别为：幽门部癌46%(11/24)，侵入淋巴结者60%(6/10)，均显著高于对照组。分化型33%(13/39)，高于未分化型者。同时表达癌的5年生存率仅46%(6/13)，显著低于各非同时表达组。结论：Cyclin E和p53同时表达的粘膜下层胃癌恶性度高，预后差；同时表达有助于预测粘膜下层胃癌的预后。

The Role of Co-expression of Cyclin E and p53 in Estimating the Prognosis of Submucosal Gastric Cancer

Li Jiaqing Wu Fei Cai Wenyan et al

    (Department of General Surgery,The First Hospital of Beijing Medical Univerity,Beijing)

Abstract Objective:To investigate the role of co-expression of cyclin E and p53 in estimating the prognosis of submucosal gastric cancer patients.Methods:The expressions of cyclin E and p53 were examined immunohistochemically in 48 cases of submucosal gastric cancer.Results:The incidence of p53 expression in cyclin egative,positive and strongly positive groups were 19%(5/27),42%(5/12) and 89%(8/9) respectively (P<0.01).The overall incidence of co-expression was 27%(13/48) and the incidence of co-expression in antrum cancer and cancers with lymph node metastasis were 46%(11/24) and 60%(6/10) respectively which were significantly higher than those of the control groups.The incidence of 33%(13/39) in differentiated type tended to be higher than that in undifferentiated type.The 5-year survival rate in co-expressed patients wasonly 46%(6/13) being significantly lower than that in non-co-expressed group.Conclusion:Since patients with co-expression of cyclin E and p53 had a poor prognosis it can be used to estimate the prognosis of submucosal gastric cncer patients.

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