王成峰 邵永孚 张海增 兰忠民 王成峰(中国医学科学院肿瘤医院中国协和医科大学肿瘤学院 北京市 100021)；邵永孚(中国医学科学院肿瘤医院中国协和医科大学肿瘤学院 北京市 100021)；张海增(中国医学科学院肿瘤医院中国协和医科大学肿瘤学院 北京市 100021)；兰忠民(中国医学科学院肿瘤医院中国协和医科大学肿瘤学院 北京市 100021) 中国肿瘤临床 2000 0 27 6


    关键词：多原发恶性肿瘤；构成比；同时性；异时性 期刊 zgzllc 0 论著 fur -->


    

摘要：目的：探讨多原发恶性肿瘤(MPMNs)的流行病学和临床特点。方法：回顾性分析我院1958～1997年收治的2011例MPMNs的构成比、发病年龄、性别比、间隔时间、好发部位。结果：MPMNs所占构成比为2.0%;平均发病年龄为50.7岁;高发年龄为50～59岁，占31.1%。性别比(男:女)为1:1.3。结论：恶性肿瘤病例中，MPMNs的发生频度似有随时间推移而增多的倾向。MPMNs的发病年龄在逐渐增大。MPMNs例数女性多于男性，但男性例数增加较快，使男女性例数逐渐接近。MPMNs的第一和第二原发癌间隔时间随时间推移在延长，但第一和二，二和三，三和四，四和五原发癌的时间间隔则逐渐缩短。MPMNs的好发器官为同一器官，成对器官和同系统的器官。

Multiple Primary Malignant Neoplasms

Wang Chengfeng Shao Yongfu Zhang Haizeng et al

    (Department of Surgery,Tumor Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing)

Abstract Objective:To explore and investigate the epidemiological and clinical features of multiple primary malignant neoplasms (MPMNs).Methods:Two Thousand and eleven cases of MPMNs patients admitted to our hospital in the period of 1958 to 1997 were studied retrospectively.including the frequency,age of onset,sex ratio,tumor location and the interval time between sequential tumors.Results:The constituent rate of MPMNs was 2%.The mean age of onset was 50.7 years and the mean age from the first to fourth decade were 45.5,45.8,8.49 and 53.9 years respectively.The peak onset age was 50 to 59 years which accounted for 31.1%.The sex ratio male vs female was 1:1.3,but in the fouth decade and senile group it was 1.1:1.The mean interval time was 7.3 years.The predilection sites were:breast 14.5%,lung 13.4%,esophagus 12.8%,uterus 12.5% and rectum 4.5%.As far as the systems were concerned,the sesceptible systems were:digestive system 20.6%,female reproductive system 16.1% and the respiratory system 13.4%.Conclusin:1) The constituent rate of MPMNs seems to have a ascending tendency.2) The age of onset is becoming older.3) Although the incidence of female is higher than male,but the incidence of male is ascending more than female.4) The interval time is ascending year bey year,but the interval time between the first and fifth tumors is decreasing.5) The susceptable organs are the identical organ,bigeminal organs and the organs of same system.

    Key Words Multiple primary malignant neoplasms Proportion Synchronic Heterochronmia

多原发恶性肿瘤(MPMNs)是指同一宿主的单个或多个器官同时或先后发生两个或两个以上原发恶性肿瘤 ......

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