安伟德 郭文斌 胡祥 张靖秋 安伟德(大连医科大学附属第一医院普外科，辽宁省 大连市 116011)；胡祥(大连医科大学附属第一医院普外科，辽宁省 大连市 116011)；郭文斌(辽宁省大连市中心医院普外科)；

    张靖秋(辽宁省营口市老边区医院外科) 中国肿瘤临床 2000 0 27 6


    关键词：乳腺肿瘤淋巴结微小转移上皮细胞膜抗原c-erbB-2 期刊 zgzllc 0 论著 fur -->


    

摘要：目的:探讨腋窝淋巴结阴性(ANN)乳腺癌淋巴结微小转移(LNM)以及原发灶c-erbB-2扩增的临床意义。方法:应用免疫组化方法对58例ANN乳腺癌LNM进行检测，利用差异PCR技术测定对应原发灶c-erbB-2扩增。结果:25.8%病例存在LNM，31.0%伴有c-erbB-2扩增；在低分化乳腺癌组中，LNM阳性率明显高于高分化组；肿瘤直径>2.0cm者的LNM检出率显著高于直径≤2.0cm患者；在LNM阳性组中，c-erbB-2扩增率明显高于阴性组。结论:免疫组化可大大提高乳腺癌病人微小转移检出率，c-erbB-2扩增在乳腺癌转移早期即可发生。

Study on Micrometastases in Axillary Lymph nodes and c-erbB2 Amplification in Axillary Node-negative Breast Cancer

An Weide Guo Wenbin Hu Xiang et al

    (First Affiliated Hospital of Dalian University of Medical Sciences,Dalian)

Abstract Objective:To explore axillary lymph nodes metastases (LNM) and c-erbB2 amplification in axillary node-negative (ANN) breast cancer and its clinical significance.Methods:The LNM was examined in 58 cases of ANN breast cancer by immunohistochemistry.The c-erbB2 amplification of tumor tissues was studied in the same patients by differential PCR.Results:The positive rate of LNM and c-erbB2 amplification were 25.8% and 31.0% respectively.In the poorly differentiated group,the positive rate of LNM was significantly higher than that of well differentiated group.In the cases of tumor >2cm,LNM rate was obviously higher than that of <2cm.In the LNM positive group,c-erbB2 amplification rate was significantly higher than that of negative group.Conclusion:The data suggest that immunohistochemical technique can greatly facilitate the detective rate of micrometastases,and c-erbB2 amplification usually occurs at the early stage of cancer metastases.

    Key Words Breast cancer Lymph node micrometastases Epithelial membrane antigen

腋窝淋巴结阴性(axillary node-negative ......

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