关键词：糖尿病；血管病变；内皮素；降钙素基因相关肽
摘要 目的： 探讨糖尿病大血管病变与血浆内皮素(ET)、降钙素基因相关肽(CGRP)的关系。方法： 采用放免法测定正常对照组47例、糖尿病无血管并发症组27例、合并大血管并发症组33例、合并微血管病变组22例、非糖尿病大血管病变组14例血浆内皮素、降钙素基因相关肽水平。结果： 糖尿病组血浆内皮素为(83.16±48.23)ng/L,降钙素基因相关肽为(78.47±57.33)ng/L,分别高于正常对照组ET(51.19±16.75)ng/L,CGRP(36.89±17.30)ng/L,有显著性差异,P<0.05。糖尿病合并大血管并发症组CGRP为(84.92±52)ng/L,较无血管并发症组CGRP(45.75±27.77)ng/L增高，P<0.05,糖尿病大血管病变组与非糖尿病大血管病变组ET、CGRP水平相比无显著性差异。结论： 糖尿病病人ET、CGRP较正常人升高，主要与血管病变有关，糖尿病病人在临床尚未出现血管病变表现时即已有血管内皮功能损害。
中国图书资料分类法分类号 R587.1
RELATIONSHIPBETWEEN THE PLASMA LEVELS OF ENDOTHELIN AND CALCITONIN GENE-RELATED PEPTIDE AND THEANGIOPATHY IN DIABETIC PATIENTS
Liu Hong,Wang Naizun,HuangRuiheng,et al
Department of Endocrinology,the FirstAffiliated Hospital Guangxi Medical University,Nanning,530021
Abstract Objective: To subjectinvestigation on the relationship between plasma levels of endothelin (ET) and calcitoningene-related peptide (CGRP) and the angiopathy in diabetic patients.Methods: Plasmaendothelin levels and calcitonin gene-related peptide levels were measured byradioimmunoassay in 47 normal subjects,27 without complication in diabetes mellitus,33with diabetic angiopathy,22 with microangiopathy,and 14 with angiopathy in non-diabeticpatients.Results： The plasma endothlin levels in diabetes groups (83.16±48.23)ng/Lwere significantly higher than those of the normal subjects (51.19±16.75)ng/L ......
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