摘要 对1992～1997年住院的36例原发性高尿酸血症肾病总结分析。其占同期原发性痛风的75%，伴有关节损害者占83%。据BUN、Scr值，将患者分为非肾衰组与肾衰组。肾衰组合并高血压者显著高于非肾衰组；两组尿渗透压/血渗透压比值几乎均<1.5；肾衰组血尿酸/血肌酐>2.5仅47%；尿尿酸排泄量肾衰组较非肾衰组显著减少。提示尿酸性肾病多数伴有关节炎，且肾功能损害进展缓慢，早期以肾小管功能损害为主。另肾衰时不能简单地根据血尿酸/血肌酐比值判断有无尿酸性肾病。

Wu Yuqiong Li Tianwang Huang Yaoning Cheng Zhujiang

    The Third Affiliated Hospital of Sun Yat-sen University of Medical Sciences,Guangzhou,Guangdong, 510630

Thirty six hospitalized patients (from 1992 to 1997) with primaryhyperuricemia were analysed, of which 75% were primary gout, 83% complicated with injuryof joint. Based on blood uric nitrogen and serum creatinine parameters, the patients weredivided into non-renal failure group and renal failure one. The ratio of urine osmoticpressure to blood osmotic pressure was almost below 1.5; only 47% of the ratio of blooduric acid to blood creatinine in renal failure group was higher than 2.5. The uric acidcapacity in the renal failure group was less than the non-renal failure group. Itindicated that most uric acid renal failure complicated with arthritis, and the renalfunction were slowly deteriorated, and the renal tubular was mainly injured in the earlystage. In addition, the uric acid renal disease can not be simply judged by the ratio ofblood uric acid to blood creatinine.

     ......