关键词：皮肤真菌病；指(趾)甲疾病；伊曲康唑
摘要 目的： 评价伊曲康唑冲击疗法治疗由皮肤癣菌、酵母菌和霉菌引起的甲真菌病的有效性、安全性和耐受性。方法： 采用冲击疗法，连续服用伊曲康唑(400 mg/d)1周后，停药3周为1个疗程。指甲真菌病服药2个疗程；趾甲真菌病服药3个疗程。观察疗程结束、停药3个月及停药6个月时指(趾)甲真菌病的临床治愈率和真菌学治愈率。结果： 疗程结束时、停药后3个月及停药后6个月时指甲真菌病的临床治愈率分别为25%、85%和90%，真菌学治愈率分别为65%、90%和95%；趾甲真菌病的临床治愈率分别为16.6%、63.3%和86.7%，真菌学治愈率分别为56.7%、83.3%和90%。疗程结束后，随时间延长治愈率不断提高，停药后6个月达最高。指甲真菌病的治愈率高于趾甲真菌病；真菌学治愈率高于临床治愈率。未发现严重不良反应。停药后6个月时复发率为6%。结论： 伊曲康唑为广谱抗真菌药，冲击疗法治疗甲真菌病具有疗效高、安全性好、耐受性高以及费用低廉的特点。
ITRACONAZOLE PULSE THERAPY FOR 50 PATIENTS WITH ONYCHOMYCOSIS
Yao Zhiyuan,Liu Yongsheng,Wang Chen,et al
(Department of Dermatology)
Abstract Objective: To evaluate the efficacy,safety and tolerability of itraconazole pulse therapy for onychomycosis due to dermatophytes,yeasts and molds.Methods: With pulse therapy,fingernail onychomycosis patients were administered an oral itraconazole 400 mg/day for one week per month for two months,toenail onychomycosis patients for three months.Results: At the end of therapy,3rd and 6 th month after therapy,in fingernail onychomycosis the clinical cure rates were 25%,85% and 90%,the mycologic cure rates were 65%,90% and 95%;in toenail onychomycosis the clinical cure rates were 16.6%,63.3% and 86.7%,the mycologic cure rates were 56.7%,83.3% and 90% respectively.The highest cure rate appeared at 6th month after therapy.The cure rate of fingernail onychomycosis was significantly higher than that of toenail onychomycosis.The mycologic cure rate was greatly higher than the clinical cure rate.No severe adverse reactions were observed.The relapse rate was 6% at 6th month after therapy.Conclusion: Itraconazole pulse therapy is effective,safe,well-tolerated and economical.
......
您现在查看是摘要页，全文长 17608 字符。