关键词：三七；萎缩性胃炎；癌前病变；病理形态；大鼠；维甲酸
摘要： 采用幽门弹簧插入加热糊复合方法复制大鼠慢性萎缩性胃炎癌前病变模型，观察三七和维甲酸对胃粘膜形态学改变的影响。结果表明三七对慢性萎缩性胃炎有较好的治疗作用，并能逆转肠上皮化生及不典型增生；维甲酸对胃粘膜病变亦有明显的改善作用，但大鼠的全身状态较差，提示中药三七治疗慢性萎缩性胃炎癌前病变具有一定优势。
Morphologic Observation of Sanqi on Rat Precancerous Lesion with
Experimental Chronic Atrophic Gastritis
Shi Xueying (石雪迎), Zhao Fengzhi (赵凤志), Dai Xin (戴 欣), et al.
(The Affiliated Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine,Beijing 100700)
ABSTRACT ： Replicate the rat model bymethods of phlorus spring insertion and hot paste, observe effects of Sanqi (Notoginseng)and tretinoin on the morphologic change of gastric mucosa. The results showed an efficacyof Sanqi on the chronic atrophic gastritis, which could also reverse the intestinalmetaplasia and atypical hyperplasia. The tretinoin had also good effect on chronicatrophic gastritis, but the rats showed a worse general condition, which suggested Sanqi'saction on precancerous lesion of chronic atrophic gastritis.
KEYWORDS : Sanqi; Atrophic gastritis; Precancerous state; Pathologic picture; Rat; Tretinoin
三七是传统的中药材 ......
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