河福金 薛占瑞 王玉清 陈学军 魏晓妍 席峥 李丰 (锦州医学院病理教研室 辽宁 121000) 北京中医药大学学报 2000 0 23 1


    关键词：大蒜素；肺动脉高压；功能；形态；大鼠 期刊 bjzyydxxb 0 39-41 中医药实验研究 fur -->


    

摘 要： 观察大蒜素对缺氧性腺泡内肺动脉高压是否具有阻抑效应，在常压缺氧条件下，选用42只大鼠，分正常组、缺氧组、缺氧加大蒜素组，分别在15d和30 d测右心室收缩压，并利用光镜、电镜观察肺血管病变。结果大蒜素不仅能降低肺动脉压，减轻缺氧对内皮细胞的损伤，还能阻抑腺泡内肺动脉肌化增强现象。提示大蒜素有明显阻抑缺氧性腺泡内肺动脉构型重组和预防缺氧性肺动脉压升高的作用，从而为该药防治肺动脉高压提供了有力的实验依据。

    分类号： R285.5

The Inhibitory Action ofGarlicin on Rat Hypoxic Pulmonary Hypertension

He Fujin,Xue Zhanrui,WangYuqing,et al.

    (Department of pathology,Jinzhou Medical College,Liaoning 121000)

Abstract： The inhibitory action ofgarlicin on structural remodeling of intra-acinar pulmonary arteries (IAPA) underpulmonary hypertension (PHT) was studied.42 rats were fed in hypoxic environment undernormal atmospheric pressure (10%O₂ 10 hours/day) and divided into controlgroup,hypoxia group and hypoxia with garlicin group.On the 15th and 30th day ofhypoxia,right ventricular systolic pressure (RVSP) was measured and pulmonary vesselchanges were studied under light and electronic microscopes rspectively.Garlicin coulddecrease the pulmonary arteries pressure and prevent IAPA endothelial cells damage fromhypoxia.Garlicin could also inhibit hypertrophic changes in tunica media,the proliferationof advantitial cells of the IAPA and muscularization ofnonmuscular arteries.Therefore,preserving the IAPA wall cells and dilating IAPA bygarlicin may play an important role in inhibiting structural remodeling of IAPA andpulmonary hypertension.

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