摘要： 为了观察通脉益智胶囊对小鼠反复脑缺血再灌流后行为学的影响，我们将40只小鼠分为4组，经反复脑缺血再灌加降血压法造模后，分别给予生理盐水、通脉益智胶囊、喜德镇灌胃，术后进行跳台、水迷宫实验测试。结果显示，模型组小鼠潜伏期缩短、游全程时间延长、错误次数增多；通脉益智胶囊组能使上述指标好转，统计学上有显著差异。本实验证实了反复脑缺血再灌流明显造成了小鼠学习、记忆功能障碍，而通脉益智胶囊可对抗此障碍，提高学习、记忆能力。

Effects of TongMaiYiZhi Capsule on Mouse Behaviorsunder Repeated Cerebral Ischemic Reperfusion Condition

Wang Hao Yan Xiaoping

    (China-Japan Friendship Hospital, Beijing 100029)

ABSTRACT: 40 mice models with vascular dementia(VD) were divided into 4 groups and administered respectively with 0.9% NS, TongMaiYiZhicapsule (TMYZ) and hydergine. Observe their behaviors in step-down avoidance test andwater-maze test. Results: The mouse's performance in the water labyrinth was obviouslyaffected. The whole-distance-swimming time was prolonged and mistakes increased. TMYZ canimprove the above indice and there was remarkable difference in statistics. It proved thatTMYZ could strengthen the mouse in learning and memory.

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