糖尿病血管病_内皮缩血管肽类

40例糖尿病患者血栓形成前期若干相关指标的变化

http://www.100md.com 《中日友好医院学报》 1999年第5期

糖尿病血管病|内皮缩血管肽类|血小板膜糖蛋白类|纤溶酶原激活物，组织型,关键词：

     林东平^* 吴万龄上海第二医科大学附属第九人民医院内分泌科，邮政编码：200011 中日友好医院学报 1999 0 13 5

    关键词：糖尿病血管病；内皮缩血管肽类；血小板膜糖蛋白类；纤溶酶原激活物，组织型期刊 zryhyyxb 0 临床研究 fur -->

摘要 目的： 观察糖尿病患者血栓形成前期血浆内皮素-1(ET-1)、血小板α-颗粒膜蛋白(GMP₁₄₀)、组织纤溶酶原激活物(tPA)及其抑制物(PAI-1)的变化。方法： 分别采用放射免疫法和发色底物显色法，检测了20例正常人和40例Ⅱ型糖尿病患者(22例无微血管病变、18例有微血管病变)的ET-1、GMP₁₄₀、tPA及PAI-1的变化。结果： 糖尿病患者的ET-1、GMP₁₄₀、PAI-1显著高于正常对照组，tPA则明显下降，伴微血管病变者比无微血管病变者变化更明显，且ET-1与GMP₁₄₀、PAI-1呈显著正相关，而与tPA呈显著负相关。结论： 上述血栓形成前期若干相关指标的测定对糖尿病微血管病变的早期诊断和病情分析有重要的临床价值。

STUDY OF SOME INDEXES RELATED TO PRETHROMBOTIC PHASE IN DIABETICS

Lin Dongping,Wu Wanling

(Department of Endocrinology,The Ninth People's Hospital,Shanghai Second Medical University,200011)

Abstract Objective: To observe changes of the plasma endothelin-1(ET-1),platelet α-granule membrane protein(GMP₁₄₀),tissue-type plasminogen activator(tPA) and plasminogen activator inhibitor(PAI-1)in diabetics.Methods: ET-1,GMP₁₄₀,tPA and PAI-1 were measured by using radioimmunoassy and developing substrate method respectively in 40 patients with type Ⅱ diabetes mellitus(18 patients with microangiopathy,22 without microangiopathy) and in the 20 controls.Results: ET-1,GMP₁₄₀ and PAI-1 were significantly higher in the diabetic patients than those in the controls,whereas tPA was obviously lower.The changes of the above indexes were more apparent in patients with microangiopathy than those without.There was significantly positive correlation between plasma ET-1 and GMP₁₄₀,PAI-1,whereas there was obviously negative correlation between ET-1 and tPA.Conclusion: The measurement of the above some indexes related to prethrombotic phase has an important value in the early diagnosis and analysis of diabetic microangiopathy.

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