聚原酸酯_载药毫微囊_控制释放

聚原酸酯抗癌药物毫微囊的制备及体外释药研究

http://www.100md.com 《中国生物医学工程学报》 1999年第2期

聚原酸酯|载药毫微囊|控制释放|抗癌药物,关键词：

     常津魏民姚康德天津大学高分子材料科学与工程研究所，天津 300072 中国生物医学工程学报 1999 0 18 2

    关键词：聚原酸酯；载药毫微囊；控制释放；抗癌药物期刊 zgswyxgcxb 0 生物医用材料 fur -->

采用W/O/W型复乳制备聚原酸酯载甲氨喋呤(MTX)毫微囊微球，通过多种条件实验，制备了聚原酸酯载药毫微囊，并对药物体外释放动力学进行研究。结果表明有机溶剂组成、内部水相药物浓度、溶剂挥发温度等均对毫微囊的结构与性能产生影响，经优化所制备毫微囊粒径在500～800nm之间，药物包封率高。

分类号： R318.08

PREPARATION AND DRUG RELEASE BEHAVIORSTUDY OF POLY (ORTHO ESTERS) ANTICANCER DRUGLOADED NANOCAPSULES

Chang Jin, Wei Min, Yao Kangde

(Research Institute of Polymeric Materials, Tianjin University, Tianjin300072)

ABSTRACT: Anticancer drug loadedpoly (ortho esters) nanocapsules were prepared using a doubleemulsification/solventevaporation technique. The release characters and the affect factors were studied. The POEnanocapsules were regular in morphology with a mean diameter of 500～800nm. The drugloaded ratio was about 30%. By using certain mixture solvent, drug concentration and lowerevaporation temperature, the satisfactory nanocapsules can be obtained.

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百拇医药网 http://www.100md.com/html/DirDu/2005/07/04/66/71/30.htm

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