何志义 吕昌龙 刘风芝 王钢 付国 吕昌龙 刘风芝 付国 基础医学院免疫学教研室；王钢 第一临床学院急诊科；何志义 中国医科大学第一临床学院神经内科，沈阳 110001 中国医科大学学报 1999 0 28 5


    关键词：多发性硬化；转化生长因子-β1；可溶性细胞间粘附分子 期刊 zgykdxxb 0 临床医学 fur -->


    

摘要 目的： 探讨可溶性细胞间粘附分子(sICAM-1)和转化生长因子-β₁ (TGF-β₁ )在多发性硬化(MS)发生、发展中的作用。方法： 采用ELISA方法，测定了30例MS患者血清中sICAM-1和TGF-β₁ 的水平。结果： 与对照组和NIND组相比，MS患者血清TGF-β₁ 水平明显下降(P<0.01)，而sICAM-1水平则明显升高(P<0.01)。动态观察显示，随着病情的好转，TGF-β₁ 水平逐渐升高，而sICAM-1水平则逐渐下降。MS患者头MRI上病灶越大，sICAM-1水平升高也越明显。结论： 血清TGF-β₁ 和sICAM-1的检测对判断MS患者的病情变化具有重要的临床实用价值。

Determining SolubleIntercellular Adhesion Molecule-1 and Transforming Growth Factor-β ₁ in Serum from Multiple Sclerosis

He Zhiyi, L Changlong, Liu Fengzhi, et al

Department of Neurology, The First Clinical College, China Medical University, Shenyang, 110001

ABSTRACT Objective: Wewere to explore the effects of soluble intercellular adhesion molecule-1 (sICAM-1) andtransforming growth factor-β₁ (TGF-β₁ ) on the development ofmultiple sclerosis (MS). Methods: Levels of sICAM-1 and TGF-β₁ in serum were measured in 30 patients with MS by ELISA method. Results: The level of TGF-β₁ decreased, and the level of sICAM-1 increasedsignificantly in the serum of MS, as compared with those in normal and non-inflammatoryneurologic disease (NIND) groups (P<0.01). The level of sICAM-1 decreased, and the TGF-β₁ levels increased after treatment of MS. The larger the sizes of foci in MRI were, the moreobviously, the level of sICAM-1 increased. Conclusion: Measuring serumsICAM-1 and TGF-β₁ might be important parameters for clinical evaluation inpatients with MS.

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