【摘要】 目的 比较福辛普利与依那普利治疗轻中度高血压病的疗效和安全性。方法 随机开放对照试验，经2周安慰剂导入期，139例轻中度高血压患者进入8周治疗期，每日1次服用福辛普利10mg(74例)或依那普利5 mg(65例)，2周后如舒张压≥90 mmHg则剂量加倍，4周后如仍无效则每日加服双氢克尿噻25mg。结果 两组药物均能明显降低血压(P<0.001)；福辛普利有效率90.1%，依那普利有效率88.9%(P>0.05)。福辛普利和依那普利组分别有38%和51%患者加用利尿剂(P>0.05)。福辛普利降压谷峰值比率59.9%，依那普利为47.1%。最常见不良反应是咳嗽，两组各4例。结论 对轻中度高血压病福辛普利是一种有效、安全且易耐受的降压药，每日1次能维持24小时降压效应。

    Comparison of fosinopril and enalapril in the treatment ofmild to moderate essential hypertension Zhu Junren,Wang Xianyan, Xu Wei, et al. Zhong Shan Hospital, Shanghai Medical University, Shanghai200032

     【Abstract 】 Objective To compare theefficacy and safety of fosinopril and enalapril in the treatment of mild to moderatehypertension. Methods Following a 2-week placeboperiod, 139 patients entered an 8-week randomized, parallel study with either 10 mgfosinopril (n=74) or 5 mg enalapril (n=65) once daily. Dose doubling and the addition ofdihydrochlorothiazide 25 mg once daily were required if diastolic blood pressure ≥90 mmHg at week 2 and week 4 respectively. Results Blood pressure were significantly reduced in both groups(P<0.001). There was no significant difference in responder rates between fosinopriltreated patients (90.1%) and patients taking enalapril (88.9%). The addition of diureticwas required in 38% of patients on fosinopril and 51% of patients on enalapril. The troughto peak ratios were calculated as 59.9% for fosinopril and 47.1% for enalapril. Cough wasthe most common side effect, observed in 4 patients in each group. Conclusion Fosinopril once daily is effective, safe and well tolerated in mildto moderate hypertensive patients.

     【Key words 】 hypertension ACE inhibitor

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