【摘要】 目的 探讨严重创伤后血清肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)水平的变化与感染性并发症的相关性。方法 选择80例重度多发性创伤患者，动态观察创伤当日，伤后第3、10、20天及出院前血清TNF-α、IL-6的变化。结果 血清TNF-α水平的变化与严重感染发生率之间的相关系数r=0.9095，P<0.01；血清IL-6水平的变化与严重感染发生率之间的相关系数r=0.9770，P<0.01。结论 重度创伤后细胞因子TNF-α及IL-6水平的升高程度与严重感染密切相关。

Relationship between the changes in serum levels of TNF-α and IL-6 andinfectious complications after severe trauma Tian Yuke, Luo Ailin, Jin Shiao. Department of Anesthesiology, Tongji Hospital, Tongji Medical University, Wuhan 430030

    【Abstract】 Objective In order to evaluate the post-traumaticchanges of serum levels of tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) andtheir relationship to the occurrence of infectious complications. Method Thechanges in serum TNF-α, IL-6 levels were observed on that day of injury, 3rd, 10th, and20th day after injury, and the day before discharge in 80 adult patients with severemultiple trauma (SMT). Result The correlation coefficients between thelevels of serum TNF-α, IL-6 and the severe infection incidence were r=0.9095, P<0.01,and r=0.9770, P<0.01 respectivly. Conclusion The increase of TNF-αand IL-6 levels in SMT patients might be closely related with severe infection.

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