常连胜 冯陶 郭应禄 姜学军 殷延林 100034 北京医科大学第一医院泌尿外科研究所 中华实验外科杂志 1999 0 16 3


    关键词：肾结石；维生素D；维生素K；动物模型 期刊 zhsywkzz 0 论著 fur -->


    

【摘要 】 目的 进一步明确维生素D和维生素K与肾结石的关系，探讨成石机制。方法 将健康成年雄性SD大鼠24只随机分成4组，即对照组、诱石组、维生素D组和维生素K组，收集第1、3、7天的24小时尿，测定尿晶体成分的浓度。结果 维生素D组尿钙和草酸明显高于对照组和诱石组，尿镁和柠檬酸显著降低(P<0.05)。维生素K组尿草酸明显低于诱石组(P<0.05)。结论 维生素D可能通过多种机制促进肾结石形成，而维生素K有抑制结石形成的作用。

Effects of Vitamin D₃ and vitamin K on urine crystal components of rat stone model

CHANG Liansheng, FENG Tao, GUO Yinglu, etal.

    Institute of Urology, Beijing Medical University, Beijing 100034

【Abstract 】 Objective Toinvestigate the relationship between kidney calculi and Vitamin D₃ as well asVitamin K. Methods Twenty-four adult male SD rats were randomly dividedinto 4 groups (control group, stone-inducing group, Vitamin D₃ group andVitamin K group). The urine were collected at day 1,3 and 7, and the crystal components inurine were detected. Results As compared with control group andstone-inducing group, the calcium and oxalate in urine were increased significantly inVitamin D group, while the magnesium and citrate were decreased significantly (P<0.05).The oxalate in urine of Vitamin K group was decreased significantly as compared with thatof stone-inducing group (P<0.05). Conclusions Vitamin D may promotestone formation through various mechanisms, whereas Vitamin K could inhibit this process.

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