【摘要】 目的 研究经肠补充谷氨酰胺(Gln)对手术病人细胞免疫功能的影响。方法 将14例手术病人随机分为Gln组(经肠补充Gln)和Non-Gln组(不补充Gln)，观察术后血浆和外周血单个核细胞(PBMC’s)内Gln含量以及PBMC’s免疫功能的变化。结果 术后第6天Non-Gln组血浆Gln水平和PBMC’s内Gln含量明显低于Gln组，补充Gln对术后PBMC’s的T淋巴细胞增殖反应、白介素2(IL-2)的生成和细胞膜白介素2受体(IL-2R)的表达均有一定的促进作用。结论 经肠补充Gln能有效维持术后血浆和PBMC’s内Gln的正常水平，改善PBMC免疫功能。

Effect of glutamine supplementation on cellular immunity in surgicalpatients YANG Juntao, WANG Zhengguo, ZHU Peifang. Department of GeneralSurgery, Daping Hospital, The Third Military Medical University, Chongqing 400042

    【Abstract】 Objective To investigate the effect of glutamine (Gln)supplementation on the immune functions of peripheral blood mononuclear cells (PBMC's) insurgical patients. Method Fourteen patients were randomly divided into aGln group and a Non-Gln group, fed enterally with or without Gln supplementation. Glnlevels in plasma and PBMC's and PBMC's immune functions were measured before and aftersurgical trauma. Result The plasma Gln level and intracellular Glnconcentration were much lower in the Non-Gln group than in the Gln group on the 6th daypostoperatively. To a certain extent, Gln supplementation could elevate T-lymphocyteproliferation response, IL-2 production and IL-2R expression in PBMC's from surgicalpatients. Conclusion Enteral Gln administration could increase Glncontent in plasma and subsequently PBMC so as to further improve PBMC immune functionsafter surgical trauma.

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