卢少明 覃伟武 莫曾南 邓耀良 李山 陈坚 卢少明 莫曾南 邓耀良 陈坚 530021 南宁，广西医科大学第一附属医院泌尿科；覃伟武 核医学科；李山 病理科 中华实验外科杂志 1999 0 16 3


    关键词：性激素；尿石症 期刊 zhsywkzz 0 论著 fur -->


    

【摘要 】 目的 探讨雄激素对尿石症患者的影响。方法 用0.5%乙二醇诱导结石形成，建立4组动物实验雄鼠模型。A组：去势结石组；B组：去势+皮下注射睾丸酮(3mg/d)结石组；C组：结石对照组；D组：正常对照组(标准无结石饮食)。4组雄鼠饲养4周后同时宰杀，分别测定和比较他们血清Testo、FSH、LH、E2、PRL、Prog,肾内晶体沉积部位及程度。结果 A、B、C各组间差异均有显著性(P<0.001)。结论 雄性激素对尿石症有一定影响。

Effect of sex hormone on the stone-inducedu rolithiasis in male rat

LU Shaoming，QIN Weiwu, CHEN Jian, MO Zengnan, et al.

    Department of Urology, The First Affiliated Hospital of Guangxi Medical University,Nanning 530021

【Abstract 】 Objective Toinvestigate testosterone in the pathogenesis of urolithiasis. Methods Fortyadult Wistar male rats were equally divided into 4 groups. The rats in group A(castrated), group B (castrated plus subcutaneous injection of Testo 3 mg/day) and group C(untreated, served stone control) were fed with 0.5% ethylene glycol (EG) lithogenic dietfor 4 weeks. The rats in group D was left untreated and served as normal controls. Thestone and crystal deposits in all groups were examined by infrared spectrometerrespectively. Serum Testo, FSH, LH, Prog, PRL and E2 were determined. Result Thestone crystal deposits among A, B, C were different from each other (P<0.001). Conclusion Testohad a certain influence on urolithiasis.

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