刘景城 王晓红 杨霁云 王素霞 苗鸿才 黄建萍 谷晓枫 100034 北京医科大学第一医院儿科 中华肾脏病杂志 1999 0 15 1


    关键词：IgA肾病；基底膜；薄基底膜病 期刊 zhszbzz 0 论著 fur -->


    

【摘要 】 目的 为了深入研究IgA肾病的临床与病理改变的关系。方法 根据肾小球基底膜(GBM)变薄的范围，将48例小儿原发性IgA肾病分为三组，对其临床、病理及其超微结构进行了系统观察，对GBM厚度进行了测量。结果 小儿IgA肾病有显著的超微结构特点。弥漫性GBM变薄组(DTBM)占14.6%，GBM厚度(129.21±29.21)nm。局灶节段变薄组(FTBM)占33.3%，GBM厚度(179.10±49.80)nm。非薄GBM组(NTGBM)占52.1%，GBM厚度(356.61±96.73)nm，分别与前两组相比，均有显著性差异(P均<0.01，t＝6.73)。结论 IgA肾病可有不同程度的GBM变薄，其厚度在230nm以下，范围在50%以上，可定义为DTBM型；范围在20%～50%之间，可定义为FTBM型。血尿可能与GBM变薄有关，但不影响预后；蛋白尿与GBM变薄无关，而与GBM病损破坏及节段足突融合有关，可能为影响预后的重要因素。

The children IgA nephropathy with the GBM thinning

LIU Jingcheng,WANG Xiaohong,YANG Jiyun,et al.Department of Pediatrics,First Hospital of Beijing Medical University,Beijing 100034.

【Abstract 】 Objective In order to study the relationship between clinic and pathology.Methods 48 children with IgA nephropathy (IgAN) were observed clinically and pathologically,meanwhile thickness of the GBM was measured.According to the degrees and ranges of GBM thinning all patients were divided into three groups.Results GBM thinning was found in children with primary IgAN.If the thickness of GBM was less than 230nm and the range of GBM thinning was more than 50%,defined as diffuse thin GBM type (DTBM).If the range of GBM thinning was between 20%～50% ......