陈宝雯 纪宝安 张学智 谢竹藩 贾博琦 100034 北京医科大学第一医院 中华消化杂志 1999 0 19 4


    关键词：积雪草提取物；胃粘膜保护；细胞因子 期刊 zhxhzz 0 论著 fur -->


    

【摘要】 目的 观察积雪草提取物(TCA)对胃粘膜损伤的防治作用及其可能的机制。方法 采用大鼠胃损伤模型，测定损伤指数、髓过氧化物酶(MPO)、丙二醛(MDA)、细胞因子、胃粘膜细胞存活率等。结果 (1)TCA对乙醇胃粘膜损伤具有预防作用；(2)对乙酸胃溃疡具有治疗作用；(3)可以降低MPO、MDA、IL-8的产生；(4)可以增加胃粘膜细胞的存活率。结论 (1)TCA对胃粘膜损伤有防治作用；(2)TCA降低血管的通透性及减少MPO、MDA、IL-8；(3)对胃粘膜细胞的直接保护作用可能是其作用机制之一。

Protection of titracted extract of centella asiatica on gastric mucosa and its possible mechanism

CHEN Baowen, JI Baoan, ZHANG Xuezhi, et al.

    Department of Gastroenterology and Chinese-West Medicine, First Hosptial, Beijing Medical University, 100034

【 Abstract 】 Objective To study the gastric mucosal protective effect of titracted extract of centella asiatica (TCA) and its possible mechanism in rats. Methods To adopt gastric damage models in rats; detect damage index; myloperoxidase (MPO); malonaldehyde (MDA); cytokines; gastric mucosal cell viability etc. Results (1)TCA could prevent gastric mucosal damage from ethanol; (2) TCA could exert therapeutic effect on gastric ulcer induced by acetic acid; (3) MPO, MDA, IL-8 were all decreased and gastric mucosal cell viability increased. Conclusion (1)TCA has preventive and therapeutic effects on gastric mucosal injury; (2) TCA reduces vascular permeability MPO, MDA and IL-8; (3)TCA has direct protective effect on gastric mucosal cell, one of its mechanism may be cytoprotection.

     【 Key words 】 TCA Gastric mucosal protection Cytokines

积雪草(centella asiatica,TCA)的提取物是一种含有多种香树脂醇型的三萜物质 ......

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