关键词：白血病；化学疗法；抗药性，多药
摘要 目的: 为建立与联合化疗相适应的体外联合药敏试验。方法: 用Chou's半效原则分析法摸索出HA、DA、AA、MA、HAD、HAA、HAM7种化疗方案各药之间的最佳联合比例,按这种比例关系,用MTT法测定了79例急性非淋巴细胞白血病(ANLL)患者对该7种方案的体外敏感性。结果 (体外/体内,S:敏感,R:耐药)：S/S67例,R/R 9例,R/S 2例,S/R 1例。与临床总符合率96.2%;阳性符合率98.5%;阴性符合率81.8%;试验敏感性97.1%;特异性88.9%。结论: 该研究探索的体外联合药敏试验与临床治疗敏感性有很好的相关性,试验敏感性与单药药敏试验相当,特异性优于单药药敏试验。
Study on combined chemosensitivity test in acute non-lymphocytic leukemia Luo Meihua ,Bian Shougeng,Xue Yanping,et al. Institute of Hematology,CAMS and PUMC,Tianjin 300020
Abstract Objective: To explore the methods of combinedchemosensitivity test in vitro.Methods: The chemosensitivity of leukemiacells to 7 kinds of combined chemotherapy regimens,including DA,HA,AA,MA,HAD,HAA andHAM,was estimated in 79 patients with ANLL by MTT assay in vitro.The ratios of drugcombinations at which synergistic interactions between drugs are to the highest levelswere determined by using Chou's “median effectanalysis”.Results: There were 67 S(sensitive)/S,9 R(resistant)/R,2 R/S,1 S/R(in vitro/in vivo) in 79 patients.Thegeneral,positive and negative coincident rates of in vitro with in vivo,specificity andsensitivity were 96.2%,98.5%,81.8%,88.9% and 97.1%,respectively.Conclusion: Thismethod is better than the single drug test,and it is more useful to find drug resistantpatients.
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