中华内分泌代谢杂志 1998 0 14 6


    关键词：糖尿病；家族史 期刊 zhnfmdxzz 0 论著 fur -->


    

【摘要】 目的 分析我国成人中糖尿病家族史阳性率及其特点。方法 对1994年我国25岁以上25万人群糖尿病调查中进行口服葡萄糖耐量试验(OGTT)(75克)后诊断的糖尿病2767例和糖耐量正常的8674例进行比较。结果 糖尿病人群中糖尿病家族史阳性率为14.0%，正常人群有糖尿病家族史者为7.4%，两者有显著性差异(P<0.001)。糖尿病人群中父亲、母亲糖尿病家族史阳性率分别为3.4%、4.0%，两者无差异。有糖尿病家族史的糖尿病患者33.6%发病年龄在25～44岁间，33.1%在45～54岁段，另33.3%的糖尿病患者发病年龄在55岁以上。而无糖尿病家族史的糖尿病患者50.2%在55岁以后发病。家族史阳性组腰臀围比(WHR)及收缩压均低于阴性组。结论 有糖尿病家族史的糖尿病患者发病年龄早，而无糖尿病家族史的糖尿病患者发病年龄晚，且向心性肥胖，收缩压升高更明显。

The prevalance andcharacteristics of family history in Chinese adult diabetics

    National Diabetes Mellitus Collaborative Group. Correspondence:Hong Jing,Yang Wenying,Pan Xiaoren.Department of Endocrinology,China-Japan Friendship Hospital,Beijing,100029

【Abstract】 Objective Toevaluate the prevalence and characteristics of family history in Chinese adult diabetics. Methods Datawere drawn from the national diabetes survey in 1994 in which 250000 adults over 25 werestudied. After oral glucose tolerance test (OGTT) (75g), there were 2767 diabetics, while8 674 individuals showed normal OGTT. Results The prevalence ofpositive family history was 14.0% among the diabetics and 7.4% among those with normalOGTT (P<0.001). The positive rates of maternal and paternal family history were 3.4% and4.0% respectively in diabetes group (P>0.05). 33.6% of the diabetics with positivefamily history developed the disease between 25-44 years of age, 33.1% between 45-54 andonly 33.3% after 55. 50.2% of the patients without positive family history developeddiabetes after 55. Both WHR and systolic pressure of patients with positive family historywere lower than those without family history. Conclusion The age ofonset of diabetes was younger in petients with positive family history than in thosewithout family history and the patients without positive family history had an obvioustendency of central obesity and high systolic pressure.

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