大肠癌_内镜超声检查_表皮生长因子受体(期刊论文)

内镜超声、表皮生长因子受体、转化生长因子β₁受体检查在大肠癌诊断中的价值

http://www.100md.com 《中华消化内镜杂志》 2000年第3期

大肠癌|内镜超声检查|表皮生长因子受体|转化生长因子β1受体,内镜超声、表皮生长因子受体、转化生长因子β1受体检查在大肠癌诊断中的价值,关键词：

     翟洪涛张齐联翟晓梅年卫东梁晋雨翟洪涛张齐联年卫东梁晋雨(100034北京医科大学第一医院外科)；翟晓梅(河南医科大学一附院外科) 中华消化内镜杂志 2000 0 17 3

    关键词：大肠癌；内镜超声检查；表皮生长因子受体；转化生长因子β_{1<；sub>受体期刊 zhxhnjzz 0 137-140 论著 fur -->

    【摘要】目的研究术前内镜超声检查(EUS)及表皮生长因子受体(EGFR)、转化生长因子β₁受体(TGFβR1)表达在大肠癌术前分期诊断中的价值。方法对35例大肠癌患者进行了EUS，并对其活检组织用免疫组化法检测了EGFR、TGF-βR₁的表达。结果EUS诊断大肠癌有无淋巴结转移准确率为77%，术前TNM分期与术后病理Dukes分期对照，准确率为74%。35例中EGFR表达阳性17例，有淋巴结转移者阳性率明显高于无淋巴结转移者，分别为80%，25%(P<0.01)。TGF-βR₁的阳性表达为54%，并与大肠癌淋巴结转移存在负相关性(P<0.05)，与大肠癌Dukes分期存在负相关性(P<0.05)。与术后病理对照，EUS及EGFR、TGF-βR₁在大肠癌淋巴结转移方面的判断是一致的。结论EGFR、TGFβR₁均是可反映大肠癌生物学行为的指标。将两种受体的检测与EUS结合起来，对目前尚不理想的术前TNM分期是一个有益的补充。
Diagnosis of colorectal cancer: roles of endoscopic ultrasonography and assays of epidermal growth factor receptor ＆ transforming growth factor - beta type Ⅰ receptor
ZHAI Hongtao

    ( Department of Surgery, First Hospital, Beijing Medical University, Beijing 100034,China )

    ZHANG Qilian

    ( Department of Surgery, First Hospital, Beijing Medical University, Beijing 100034,China )

    ZHAI Xiaomei

    ( Department of Surgery, First Hospital, Beijing Medical University, Beijing 100034,China )
【 Abstract 】 Objective The roles of endoscopic ultrasonography (EUS) and assays of epidermal growth factor receptor (EGFR) and transforming growth factor beta type Ⅰ receptor (TGF -β R₁) in diagnosing colorectal cancer was evaluated. Methods EUS was exercised on 35 patients with colorectal cancer. The biopsied tissues were assessed for expressions of EGFR and TGF -β R₁ with immunohistochemistry. Results With EUS the diagnostic accuracy for lymphatic metastasis fell in 77 percent, while the percentage of accuracy of staging with preoperative TNM standards as compared with postoperative Dukes ’ was 74. EGFR expressed positively in 17/35 cases with a higher positivity in those who had lymphatic metastasis than those had not (being 80 % and 25 % respectively, P<0.01).Whereas TGF -β R₁ positive expression was found in 54 percent of individuals with a negative correlation (P< 0.05) in terms of lymphatic metastasis and Dukes ’ staging (P< 0.05). With regard to predicting colorectal lymphatic metastasis the findings of EUS, EGFR and TGF -β R₁ were in accordance with that of pathology. Conclusion Since EGFR and TGF -β R₁ are the criteria capable of standing for the bio - behaviour of colorectal cancer, combination of these assessments with EUS may be a supplement to the imperfect TNM staging.

    【 Key words 】 Colorectal carcinoma; Endoscopic ultrasonography ; Epidermal growth factor receptor ;Transforming growth factor - beta type Ⅰ receptor
术前明确原发癌肿的病变范围 ......

    百拇医药网 http://www.100md.com/html/DirDu/2005/07/05/66/07/98.htm

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