【摘要 】 目的 探讨粉防己碱(Tet)对膀胱出口梗阻(BOO)大鼠膀胱胶原纤维增生及相关形态学改变的影响。 方法 将30只SD大鼠分为假手术组、BOO组、Tet组，术后6周分别观察其膀胱组织学、超微结构的变化并计算胶原纤维含量。 结果 Tet组较BOO组膀胱胶原纤维明显减少，平滑肌束及肌细胞间隙变窄，中间连接破坏减少。 结论 Tet能抑制膀胱胶原纤维增生。

【Abstract 】 Objective Toinvestigate the effects of tet randrine on collagen hyperplasia and the relatedmorphological changes in rat ur inary bladder with outflow obstruction. Methods 30SD ra ts were randomly divided into the operation group, the bladder outlet obstructio ngroup and the tetrandrine group.After the 6th week,bladder morphology was stud ied withlight and electron microscopy.The area density of collagen fibrils of t he bladder tissuewas calculated by computer-assisted quantitative image analys is system. Results Theresult indicated that tetrandrine could inhibit the collagen hyperplasia,narrow the septumof smooth muscle cells and decrease the lesion of intermediate cell junctions. Conclusions Tetrandrine would inhibit the hyperplasia of bladder collagen fibri ls.

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