吴刚 那彦群 孔祥田 宓培 夏同礼 薛兆英 郭应禄 100034 北京医科大学第一临床医院泌尿外科、北京医科大学泌尿外科研究所 中华泌尿外科杂志 1999 0 20 5


    关键词：前列腺增生,雄激素,受体,生长因子 期刊 zhmnwkzz 0 论 著 fur -->


    

【摘要 】 目的 探讨雄激素受体(AR)与转化生长因子-βⅠ型受体(TGF-β RⅠ)在良性前列腺增生(BPH)组织中表达的意义及其相关性。 方法 采用免疫组化法研究两种受体在31例BPH和22例正常前列腺标本中表达的状况。 结果 AR和TGF-β RⅠ在BPH上皮、间质组织中的表达显著高于正常前列腺组织(P <0.05)；在BPH间质组织中AR和TGF-β RⅠ的表达呈正相关(相关系数r =0.358，P <0.05)。 结论 AR和TGF-β RⅠ在前列腺增生组织中表达增高，两者之间具有协同作用，提示两者在前列腺中的过表达可能参与了BPH的发生和病理过程。

Expressions of androgen receptor and TGF-β RI in benign prostatic hyperplasia WU Gang ,NA Yanqun ,KONG Xiangtian ,et al .Institue of Urology ,Beijing Medical University ,Beijing 100034

【Abstract 】 Objective To investigate the expressions of androgen receptor (AR) and transforming growth factor β receptor Ⅰ (TGF-β RI) in benign prostatic hyperplasia (BPH). Methods AR and TGF-β RI expressions were detected in 31 human prostatic hyperplasia tissue specimens and in 22 normal prostatic tissues as controls. Results Positive expressions of AR and TGF-β RI were much higher in the epithelial and mysenchymal of BPH than those in normal prostatic tissue (P <0.05) and expression of AR was signigicantly associated with that of TGF-β RI in stromal tissue of BPH (r =0.358,P <0.05). Conclusions Expressions of AR and TGF-β RI might play a role in the regulation of the growth of prostatic tissue and therefore might be a causative factor in prostatic hyperplasia.

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