摘要 为研究环孢素A(CsA)降低血镁的作用及其机制，探讨CsA诱导的低血镁是否与肾移植后高血压有关，以硫唑嘌呤(Aza)治疗组为对照组，以CsA治疗血压正常组和CsA治疗高血压组为研究组，检查了各组血镁浓度和镁排泄分数。结果：Aza组、CsA血压正常组、CsA高血压组的血镁浓度分别为0.82±0.05mmol/L、0.75±0.06mmol/L、0.66±0.08mmol/L，两两比较有显著性差异(P<0.05)；镁排泄分数分别为：6.4%±2.3%、7.5%±3.6%、8.8%±3.9%，两两比较有显著性差异(P<0.05)；低镁血症发生率分别为：6.7%、55.0%、81.1%，两两比较有显著性差异(P<0.05)。结果提示：CsA能引起肾移植患者血镁显著下降，这种低血镁可能是肾性镁丢失的结果，与肾移植后高血压相关。

Cyclosporine and Hypomagnesemia inRenal Transplant Patients ZhangShilin,Min Zhilian,Zhu Youhua,et al.Renal Transplantation Center of ChangzhengHospital,Second Military Medical University of PLA,Shanghai 200003

    Abstract To study the effects of Cyclosporine on magnesium metabolism inrenal transplant patients and to determine whether CsA-induced hypomagnesemia wasassociated with post transplant hypertension,three patient groups were studied:15 Aza-treated patients (groupl);20 CsA-treated patients with normal blood pressure(group2);32 CsA-treated patients with hypertension (group3).Serum magnesium and fractionalexcretion of magnesium were monitored.Serum magnesium in group 1,2,3 was 0.82±0.05mmol/L,0.75±0.06mmol/Land 0.66±0.08mmol/L,respectively (P<0.05);Fractionalexcretion of magnesium in group 1,2,3 was 6.4±2.3%,7.5±3.6% and 8.8±3.9%,respectively(P<0.05);6.7%,55.0%,81.1% of group 1,2,3 (P<0.05) respectively was noted to have hypomagnesemia.Our studyindicates CsA may induce significant low serum magnesium in renal transplantpatients,which is the result of urinary magnesium loss and is associated with posttransplant hypertension.

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