徐爱强 宋立志 王常银 王爱莲 许青 肖作奎 王少华 李漫时 郝 淑珍 李震 徐爱强, 宋立志, 王常银, 王爱莲, 许青, 肖作奎, 王少华, 李漫时, 郝淑珍, 李震(山东省卫生防疫站计划免疫科 250014 济南) 中华流行病学杂志 2000 0 21 2


    关键词：风疹疫苗；免疫持久性；血凝抑制抗体 期刊 zhlxbxzz 0 论 著 fur -->


    

摘 要：目的 研究婴幼儿接种国 产BRDⅡ株风疹减毒活疫苗后的免疫持久性。方法 以血凝抑制(HI)抗体方法，选择城区既往无风疹感染和风疹疫苗免疫史的6～18月龄组婴幼儿 ，对其接种风疹疫苗1年和2年后的抗体水平进行检测。结果 在6、 7、8、9、12和18月龄组初免获得成功的儿童中，接种风疹疫苗1年和2年后，各组HI抗体阳 性率仍分别高达94.44%、97.22%、96.67%、100.00%、100.00%、100.00%和93.10 %、93.55%、96.77%、 96.97%、100.00%、100.00%(P>0.05)，但免后1年和2年的GMRTs则分别较免后1个月和免后1年约降低了50%，且免后2 年6～7月龄组的GMRTs(29.89)显著低于8～18月龄组(53.00)的结果(t＝3.58 ，P<0.001)。结论 国产风疹疫苗起始免疫月龄不宜太 小，以儿童出生后8月龄为宜，加强免疫的时间可暂时参考国外目前已实行的免疫方案。

    

An observation of the immuno-persistence after inoculating with the domestic BRDⅡ strain rubella vaccine among infants and young children

XU Aiqiang SONG Lizhi WANG Changyin, et al.
( Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014, China)

Abstract： Objective To study the immuno-persistence after inoculating with the domestic BRDⅡ strain rubella vaccine among infants a nd young children. Methods Hemagglutination inhibition (HI) antibody detecti on method was used to test on children at age 6 to 18 months without rubella inf ection or rubella vaccine immunization in Yantai city of Shandong province and w ere selected for the observation of the immuno-persistence against the domestic BRD Ⅱ strain rubella vaccine from 1995 to 1998. Results Positive rates of HI antibody among children of 6 ,7,8,9,12 and 18 month-old of inoculation were 94.44%,97.22%,96.67% ,100.00%,100.00%,100.00% and 93.10%,93.55%,96.77%,96.9 7%,100.00%,100.00% (P> 0.05),in one or two years nespect ively. The geometric mean reverse titers (GMRTs) were about 50% lower than that after 1 month after 1 year. Similar resutls were found that after 2 years GMRTs w as about 50% lower than that after 1 year of inoculation. There was highly signi ficant difference on GMRTs of HI antibody between infants with 6 to 7 month-old s (29.89) and young children with 8 to 18 month-olds (53.00) after 2 years of i noculation (t＝ 3.58,P< 0.001).Conclusion The immunization schedule at the first dos e fo r BRDⅡ strain rubella vaccine should be started when the child is 8 month old. For the second dose, the immunization schedule used in other developed countries should be referred adopted in China.
Key words ： Rubella vaccine; Immuno-persistence; Hemag glutination inhibition antibody

为科学制订国产BRDⅡ株风疹减毒活疫苗的免疫程序 ......

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