关键词：结核，肺；结核，抗多种药物性
摘要 目的 探讨老年肺结核患者痰结核菌的耐药情况。 方法 采用BACTEC法对134例老年痰菌阳性肺结核患者痰结核分支杆菌做耐药性检测。 结果 老年肺结核患者初始耐药率为36.8%，显著低于获得性耐药率的75.9%(P<0.01)；耐异烟肼(INH,H)、利福平(RFP,R)、链霉素(SM,S)前者亦明显低于后者(P<0.01)。初治组耐2和3种药比例为6.6%和5.3%，与复治组的22.4%和27.7%相比差异有显著性(P<0.01)。至少耐异烟肼和利福平两种药的比例，初治组为9.2%，显著低于复治组的50.0%(P<0.01)。 结论 老年人肺结核耐药情况严重，尤其是获得性耐药和耐多药比例偏高，应引起足够重视。
Drugresistance in 134 aged patients with pulmonary tuberculosis
Yue Licheng, WangYingnian, Zhang Kejia, et al.The Second Affiliated Hospital of Qingdao MedicalCollege,Qingdao 266042
Abstract Objective Todetermine resistance pattern to anti-tuberculosis drugs in aged pulmonary tuberculosispatients. Methods Drug sensitivity test was carried out by BACTEC in 134 cases. Results Drugresistance was found in 36.8% of new cases, which was significantly lower than that(75.9%) of recurrent cases(P<0.01) and so did theresistance to isoniazid (INH), rifampin(RFP) and streptomycin (SM)(P<0.01). About 6.6% and 5.3% in new cases were resistant to two andthree drugs, while 22.4% and 27.7% in recurrent cases (P<0.01). Resistance to both INH and RFP at least in new cases was9.2% and in recurrent cases was 50.0%(P<0.01). Conclusions Thissurvey indicated that drug resistance in aged pulmonary tuberculosis patients was serious,especially the high acquired resistance and multi-drug resistance.
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