亚洲戊型肝炎病毒结构蛋白的变异
戊型肝炎病毒|基因漂移,关键词:
关键词:戊型肝炎病毒;基因漂移
【摘要】 目的 了解戊型肝炎病毒的变异。方法 用双脱氧法对亚洲主要戊型肝炎流行国家的戊型肝炎病毒结构基因区段进行了分析,并根据cDNA序列确定了其氨基酸的序列。结果 证明亚洲国家包括印度、缅甸、中国、巴基斯坦、吉尔吉斯坦流行的戊型肝炎病毒在基因水平和氨基酸水平上均有变化,核苷酸变化幅度在5%以内。氨基酸在测定的区域内未发现变异,与美洲发现的墨西哥株相比,亚洲株拟来自同一个祖先,基因和氨基酸水平的变化仅属基因漂移的范围。结论 以亚洲戊型肝炎病毒基因为基础的疫苗将有广泛的保护作用。
Genome shift of hepatitis E virus in Asia Bi Shengli,Zhuang Hui, Liu Chongbai, et al. Institute of Virology,Chinese Academy of Preventive Medicine,Beijing 100052
Abstract Dideoxy chain termination method was applied to sequence hepatitis E virus structure gene of Asia isolates,cDNA sequence and amino acid residues were determined. The results showed that among Asia countries: Indian, Burma, China, Pakistan and Kirghiz Republic,Hepatitis E virus genome shifted within the range of 5% and amino acid residues shifted within 1% compared with Mexico isolate.Asia Hepatitis E virus isolates have limited genome shift,which suggests recombinant Hepatitis E vaccine based on Asia HEV gene might protect all HEV infection in this area.
......
您现在查看是摘要页,全文长 26099 字符。