郝超 姜维平 王亚龙 陈文宇 沈洪兵 徐耀初 郝超、姜维平、王亚龙、陈文宇 213003 江苏省常州市卫生防疫站；沈洪兵、徐耀初 南京医科大学 中华流行病学杂志 1999 0 0 6


    关键词：Ⅱ型糖尿病；家族聚集性；流行病学 期刊 zhlxbxzz 0 论著 fur -->


    

【摘要】 目的 探讨家族遗传因素在Ⅱ型糖尿病发生发展中的作用。方法 采用遗传流行病学病例对照研究方法，对常州市350个家系(184个Ⅱ型糖尿病先证家系和166个对照家系)进行了Ⅱ型糖尿病的遗传流行病学研究。结果 病例组一级亲属总的患病率为3.47%，与对照组的1.03%相比，差异有非常显著性(χ² =17.66,P<0.01)；无论其父母、同胞或子女，均以病例亲属的患病率显著高于对照;Ⅱ型糖尿病家族中实际发病数超过其二项分布的理论概率范围，即Ⅱ型糖尿病的分布呈明显的家族聚集性;单因素和多因素logistic回归模型拟合也提示，家族史仍是Ⅱ型糖尿病的最主要危险因素。结论 遗传因素在Ⅱ型糖尿病发病中占有重要地位。

    

An epidemiologic study onfamilial aggregation in non-insulin-dependent diabetes mellitus (NIDDM)

HAO Chao,JIANG Weiping,WANG Yalong, et al.

Changzhou Anti-epidemic Station,Changzhou 213003

【 Abstract】 Objective To study the relationship between genetic factors and thedevelopment of NIDDM. Methods A case-control study including 350 pedigrees (184 casesand 166 controls) was carried out to explore the etiology of family aggregation of NIDDMin Changzhou city,March 1997. Results The total prevalence rate of the first-degree relativeswas 3.47%, significantly higher than 1.03% in controls (χ ² =17.66,P< 0.01). The similar results were also found in theirparents, siblings and younger generation. Results Results from binominal distribution analysis showed thatthe number of cases in the families of NIDDM was significantly bigger than the theoreticalrange, indicating that there was significant familial aggregationin in the occurance of NIDDM. Simple and multiple logistic regression analysis also showed that genetic factorwas one of the most important factors in the development of NIDDM. Conclusion Genetic factor was animportant factor in the occurance of NIDDM.

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