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关键词：肿瘤，基底细胞；前列腺；前列腺肿瘤
摘要 目的 探讨前列腺基底细胞增生和肿瘤的形态学和免疫组化特征，提供诊断依据。 方法 选取26例的前列腺基底细胞增生和肿瘤标本，分别作HE和免疫组化染色，光镜下观察。 结果 显示增生的基底细胞比正常增大，核呈卵圆形或梭形，常呈双层腺样、实体和筛状结构和34βE12阳性反应特征。本组特征表现为6型，即基底细胞灶性增生、基底细胞非典型性灶性增生、基底细胞腺瘤样增生、基底细胞非典型性腺瘤样增生、腺样基底细胞瘤和基底细胞癌。 结论 基底细胞增生和肿瘤具有与分泌细胞不同的形态学和免疫组化反应特征，其特征可表现为6型。
An observation on the morphology and immunohistochemistry of basal cell hyperplasia and tumor of the prostate
Peng Jieqing , Yu Li, Bao Juying, et al. Department of Pathology, Tongji Medical University, Wuhan 430030
Abstract Objective To study the characteristics of morphology and immunohistochemistry of basal cell hyperplasia and tumor of prostate in order to provide evidences for its diagnostis. Methods Specimens from 26 cases of basal cell hyperplasia and tumor of prostate were studied with HE and immunohistochemical stains by light-microscopy. Results The hyperplastic basal cells were characteristically larger than normal, with oval or spindle nuclei, and formation of double layer-glandlike, solid or cribriform patterns, stained positive for 34βE12. Accordingly 6 types were categorized: i.e. basal cell focal hyperplasia, basal cell atypical focal hyperplasia, basal cell adenomatoid hyperplasia, basal cell atypical adenomatoid hyperplasia,adenoid basal cell tumor and basal carcinoma. Conclusions Basal cell hyperplasia and tumors have different features of morpholoy and immunohistochemistry in constract to that of secretory cells, and based on these fertures 6 types were categorized.
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