曲芬 姜素椿 王力娜 王殿军 赵景民 张维国 李瑞霞 郭云娣 100039 北京，解放军第302医院(曲芬、姜素椿、赵景民、张维国)；武警总医院(王力娜、李瑞霞)；解放军总医院病理科(王殿军)；内蒙古自治区赤峰卫生学校(郭云娣) 中华内科杂志 1998 0 37 4


    关键词： 期刊 zhnkzz 0 环丙沙星胎儿发育软骨 fur -->


    

【摘要 】 目的 了解孕妇应用喹诺酮类药物是否会影响胎儿的软骨发育。方法 采用微生物法测定了10例因感染而口服环丙沙星(ciprofloxacin, CPLX)的中晚期引产孕妇的血浆、羊水及胎儿血浆、软骨中药物浓度，并观察了胎儿软骨的形态学改变。结果 母血、羊水、脐血及胎儿软骨中CPLX浓度分别为1.83、1.35、0.65 mg/L及1.11 μg/g软骨。胎儿软骨结构在光镜下未见明显改变，但超微结构观察发现软骨细胞水肿、退形性变，基质丢失。结论 喹诺酮类药物能引起胎儿关节软骨细胞不同程度损伤，孕妇应尽量避免使用喹诺酮类药物。

A study on the effects of ciprofloxacin on fetal cartilage Qu Fen^* , Jiang Suchun, Wang Lina, et al. ^* The 302nd Hospital of Chinese PLA, Beijing 100039

     【 Abstract 】 Objective To study whether quinolone agents can penetrate the placenta and what is its level in fetal cartilage. Methods The concentrations of ciprofloxacin in maternal blood plasma, amniotic fluid and fetal blood plasma and cartilage were determined in ten pregnant women taking oral ciprofloxacin because of infection and undergoing termination of gestation between 19 and 34 weeks. At the same time, the effect of the concentrations of ciprofloxacin on the morphology of fetal cartilage was tested. Results The concentrations of ciprofloxacin in maternal blood plasma, amniotic fluid, fetal blood plasma and cartilage were 1.83, 1.35, 0.65 mg/L and 1.11 μ g/g cartilage respectively. Although there was no significant change of the fetal cartilage in light microscopy, yet specific alteration was found in electron microscopic studies. Conclusion Ciprofloxacin can cause lesions in fetal cartilage and its use should be avoided in pregnant women.

     【 Key words 】 Ciprofloxacin Fetal development Cartilage

喹诺酮类(Quinolones, QNS)药物能否在孕妇及儿童中安全应用是个悬而未解的问题 ......

    百拇医药网 http://www.100md.com/html/DirDu/2005/07/06/65/04/91.htm

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