陈江浩 张洪新 黄学胜 王执民 刘锟 白建军 710038 西安，第四军医大学唐都医院介入放射科[张洪新、(研究生)、陈江浩、王执民]，胸外科(刘锟)，放射科(白建军)；解放军第九一医院胸外科(黄学胜) 中华肿瘤杂志 1998 0 0 5


    关键词：肺肿瘤/放射摄影术 肺肿瘤/病理学 断层摄影术，X线计算机 p53蛋白增殖细胞核抗原 免疫组织化学 期刊 zhzlzz 0 临床研究 fur -->


    

【摘要】 目的 研究周围型肺癌CT征象与p53蛋白及增殖细胞核抗原(PCNA)表达间的关系。方法 运用SP免疫组化法，检测32例经病理证实的周围型肺癌组织中p53蛋白及PCNA的表达,并回顾性分析其与术前CT征象间的关系。结果 p53蛋白、PCNA表达与瘤体大小、深分叶征、空洞、胸膜凹陷征、纵隔淋巴结转移有关,与毛刺征无关。结论 周围型肺癌CT征象中，瘤体直径>3cm,或出现深分叶征、空洞、胸膜凹陷征、纵隔淋巴结转移者，具有相对更高的恶性程度,肿瘤细胞的增殖更为活跃。

    Study on the correlation between CT features and expression of p53 protein and PCNA inperipheral lung cancer Chen Jianghao, Zhang Hongxin, Huang Xuesheng, et al.Department of Interventional Radiology, Tangdu Hospital, Fourth Military MedicalUniversity, Xian 710038

    【Abstract】 Objective To investigate the correlation between CT features andexpression of p53 protein and PCNA in peripheral lung cancer. Methods The expression ofp53 protein and PCNA was examined by means of SP immunohistochemical technique in 32 casesof peripheral lung cancer proved by pathology; the relationship between the results andpreoperative CT features was analyzed retrospectively. Results The expression of p53protein and PCNA was correlated with tumor size, deep lobulation, frank cavitation,pleural indentation and mediastinal lymph node metastasis, but not with spiculation.Conclusion The CT features of peripheral lung cancer with diameter more than 3 cm, deep lobulation, frank cavitation, pleural indentation or mediastinal lymph node metastasisindicate higher degree of malignancy and proliferative activity of tumor cells.

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