刘化驰 杨秉辉 潘志刚 任正刚 刘银坤 汤钊猷 200032,上海医科大学中山医院. 中华肝脏病杂志 1999 0 7 1


    关键词：癌,肝细胞 受体,转化生长因子β 预后 放射配位体测定 期刊 zhgzbzz 0 临床研究 fur -->


    

摘要 目的 研究转化生长因子βⅠ型(TβRⅠ)受体在人肝癌组织中的表达，探讨其临床意义。方法 以¹²⁵ I-TGF-β₁ 为配体的放射性配体结合分析法，检测了TβRⅠ在30例肝癌组织及癌周肝组织和4例正常对照肝组织中的表达。分析了肝细胞癌组织中TβRⅠ相对表达率与肝癌的一些临床病理资料的关系。结果 肝癌组织TbRⅠ表达较癌周肝组织及正常肝组织明显降低(P <0.01)，后两者间TβRⅠ表达一致。包膜侵犯/无包膜组和伴血管癌栓组TβRⅠ表达率明显降低(P <0.05)。TβRⅠ相对表达率与年龄、性别、HBV感染、肝硬化、AFP、肝癌的大小、数目及分化程度无关(P >0.05)。结论 肝癌组织中TβRⅠ表达降低可能是肝癌拮抗TGF-b对其生长抑制作用而恶性演进的关键因素，TβRⅠ相对表达率与肝癌的预后有关。

    

Relationship between the expressionof transforming growth factor b type Ⅰreceptor (TβRⅠ) and prognosis of hepatocellularcarcinoma (HCC)

LIU Huachi,YANG Binghui,PAN Zhigang,et al.Liver Cancer Institute,Zhongshan Hospital,Shanghai Medical University,Shanghai 200032

Abstract Objective Tostudy the expression of TβRⅠ in HCC tissues and its clinical significance.Methods Expressions of TβRⅠ in HCC tissues (HT,n=30) and surrounding liver tissues(HST,n=30) aswell as four normal control liver tissues (CIT,n=4) were determined by radioligand bindingassay with 125I TGFβ1 as the ligand.Relationships between some clinicopatholgicalparameters of HCC and the relative expression rates of TβRⅠ in HCC were studied.Results Compared with that in HST,the expression of TβRⅠ in HT was significantly lower than inHST and CIT (P<0.01).The expression of TβRⅠ in HST is similar to that in CIT.TβRⅠrelative expression rates in the group of no capsule or capsule invaded and in the groupof tumor embolus were markedly decreased (P <0.05).No close relationships werefound between the TβRⅠ relative expression rate and age,sex,HBV infection,livercirrhosis,AFP concentration ,tumor diameter,tumor number,tumordifferentiation as well as tumor embolus.Conclusions The low expression of TbRⅠ in HTmay be one of the key event which promote the HCC malignant growth by protecting themagainst the growthinhibition effect of active TGFb.The TβRⅠ relative expression ratemay be related to the prognosis of HCC.

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