崔书钟 李国辉 510095 广州市肿瘤医院腹外科(崔书钟)；广州，中山医科大学附属肿瘤医院腹外科(李国辉) 中华肝脏病杂志 1998 0 0 1


    关键词：肝 肿瘤 受体 雌激素 孕激素 期刊 zhgzbzz 0 临床研究 fur -->


    

【摘要】 目的 研究雌、孕激素受体作为肝癌标志物的意义。 方法 采用放射性配基结合分析法(RBA)测定了63例行手术切除的肝癌组织、癌周组织及7例非肝癌肝组织的雌、孕激素受体的含量并结合临床资料进行统计分析。 结果 (1)三种组织中存在雌、孕激素受体。(2)肝癌组织与癌周组织中雌、孕激素受体含量无明显差别，肝癌组织与癌周组织分别与非肝癌肝组织相比，雌激素受体的含量无明显差别，孕激素受体的含量有明显差别。(3)肝癌根治术后一年复发组的肝癌组织中雌、孕激素受体的含量与未复发组相比，无明显差别。 结论 肝癌的发生可能与肝癌组织中孕激素受体含量的降低有关，雌、孕激素受体与肝癌术后的复发没有关系。

    

DISTRIBUTION OF PROGESTERONE RECEPTOR AND ESTROGEN RECEPTOR IN PRIMARY LIVER CANCER AND ITS CLINICAL SIGNIFICANCE

Cui Shuzhong, Li Guohui. Guangzhou Tumor Hospital, 510095

【Abstract】 Objective To explore the significance of estrogen receptor (ER) and progesterone receptor (PgR) as a tumor-marker of liver cancer. Methods Receptor binding assay (RBA) was adopted to measure the distribution of PgR and ER in liver cancer and tissue in its vicinity in 63 patients with primary liver cancer (PLC) undergone laparotomy and in non-tumor liver tissue in 7 cases with gastric carcinoma. Results (1)PgR and ER was demonstrated in the liver cancer tissue and surrounding non-tumorous tissue, and the non-tumor liver tissue. (2) There was no difference in the amount of PgR and ER between the tumor tissue and tissue surrounding it. The expression of PgR in the liver cancer tissue or the surrounding tissue was less marked than that in the non-tumor tissue. There was no difference in the amount of ER between the surrounding non-tumorous tissue and the non-tumor liver tissue. (3)Expression of PgR and ER in the tumor tissue did not seem to correlate with more frequent tumor recurrence one year after radical resection. Conclusion The occurrence of PLC probably has some relationship with reduced quantities of PgR, and the quantities of ER and PgR have no relationship with the recurrence of PLC after operation.

     ......