石小枫 张定凤 徐曼 400010 重庆医科大学病毒性肝炎研究所(石小枫、张定凤)；重庆医科大学病理教研室(徐曼) 中华肝脏病杂志 1998 0 0 1


    关键词：肝心康 肝纤维化 期刊 zhgzbzz 0 基础研究 fur -->


    

【摘要】 目的 观察肝心康抗大鼠实验性肝纤维化作用。 方法 制备大鼠实验性肝纤维化模型，用肝心康治疗；观察肝组织病理形态变化，Ⅰ、Ⅲ型胶原的形成、羟脯氨酸含量及血清PCⅢ含量。 结果 肝心康治疗组的纤维化程度较模型组明显为轻；模型组肝细胞微绒毛肿胀，数量减少，Diss间隙内可见多量的胶原纤维及贮脂细胞增生，肝心康治疗组肝细胞内线粒体，内质网较正常，Diss间隙内仅见极少量胶原纤维束，贮脂细胞增生不明显；免疫组织化学证明肝心康能抑制Ⅰ、Ⅲ型胶原的合成，其血PCⅢ及肝羟脯氨酸含量较模型组明显为低。 结论 肝心康的抗肝纤维化作用是有效的。

    

EXPERIMENTAL STUDY OFEFFECT OF GAN XIN KANG (GXX) ON LIVER FIBROSIS IN RAT

Shi Xiaofeng, Zhang Dingfeng,Xu Man. Institute of Viral Hepatitis, Chongqing University of Medical Sciences, 400010

【Abstract】 Objective To observethe effect of GAN XIN KANG (GXK) on the experimental liver fibrosis in rat induced bycarbon tetrachloride. Methods The wistar rats were randomizedly divide into normal control group,liver fibrotic model group induced by carbon tetrachloride and GXK treatment group. At theend of experiment, liver tissue was studied with histopathological and immunohistochemicalassay. Results In the morphologic observation, degress of the liver fibrosis ofthe groups treated by GXK were markedly lessened as compared with those of the grouptreated with clchicine and group untreated. The deposition of type Ⅰ and Ⅲ collagen on livertissue was significantly decreased in immunohistochemical stain. On electronin microscopy,deposition of collagen was markedly decreased and produce of fat-storing cells weredepressed after GXK treatment. The PCⅢ level inserum and hydroxyproline contents in liver were decreased in the group treated by GXK. Conclusion Theresults suggested that GXK was effective for antifibrosis in experimental model in rat andmight be better than those of colchicine.

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