王义生 毛克亚 李月白 450052 郑州，河南医科大学第一临床医学院骨科(王义生、在读硕士：毛克亚)； 河南医科大学基础医学院生化教研室(李月白) 中华骨科杂志 1998 0 0 4


    关键词：股骨头坏死；酒精性；骨细胞；脂沉积 期刊 zhgkzz 0 基础研究 fur -->


    

摘要 采用灌胃法给予家兔烈性酒(含乙醇45%)10ml/(kg· d)共1～6个月，观察其血清学、肝脏和股骨头组织学变化。结果表明血清LPO、GGT、ALT、AST、TG和CHO升高,SOD降低。肝脏脂肪浸润。股骨头髓内脂肪细胞增多、增大,空骨陷窝百分比升高,骨小梁变细、稀疏，面积分数降低。透射电镜下见股骨头软骨下骨细胞内脂质沉积，甚或脂肪充满整个骨陷窝，骨细胞固缩、死亡。提示长期过量饮酒可导致股骨头缺血性坏死。

    An Experimental Study on the Pathogenesis ofAlcohol-induced Avascular Necrosis of the Femoral Head Wang Yisheng, Mao Keya, Li Yuebai. Department of Orthopaedics, TheFirst Affiliated Hospital of Henan Medical Universidy，Zhengzhou 450052

     Abstract In this experimental study, The rabbits were administered the winecontaining 45% of alcohol at dosage of 10 ml/(kg*d) by pouring into stomach with a plastictube for 1 to 6 months.The results showed that serum lipid peroxides(LPO),gamma-glutamyl-transferase(GGT), aspartate amino transaminase(ALT),asparticacid transaminase(AST) , triglycerid( TG) , cholesterol(CHO)level increased and SODactivity reduced in alcohol treated animals. Histopathological study revealed that therewere fatty infiltration in the liver and increase and enlargement of fat cell in thefemoral head marrow. The percentage of empty osteocyte lacunae was incresed and thetrabeculace became thinner and sparse, and decreased in fraction. The transmissible electron microscope study of the ostecytes insubchontral area of the head demonstrated that there were a lipid deposition inosteocytes,the fat filled entirely in the osteocyte lacunae, and the osteocytes becamepyknosis and death in the alcohol group. All of these evidence suggested the long-termexcessive intake of the wine may induce the avascularnecrosis of the femoral head.

     Key words Key words Femur head necrosis Alcoholic Osteocytes Lipiddeposition

过量饮酒引起股骨头缺血性坏死(avascular necrosis of the femoral head ......