袁克俭 许伟石 杨惠忠 章雄 吴晓武 黄伯高 200025 上海第二医科大学附属瑞金医院烧伤科 中华整形烧伤外科杂志 1998 0 14 2


    关键词：冬眠药物；皮质酮；儿茶酚胺 期刊 zhzxsswkzz 0 论著 fur -->


    

【摘要】 目的 探讨烧伤早期液体复苏同时给予冬眠药物是否能削弱神经内分泌的过度反应。方法 用兔15%TBSAⅢ度烫伤模型。冬眠药物组在液体复苏的同时给予冬眠合剂，而对照组仅液体复苏。分别于伤后4，8，24，48和72小时测定血浆皮质酮和儿茶酚胺水平。结果 冬眠药物组血浆皮质酮和血浆去甲肾上腺素水平显著低于对照组(P<0.05)，而肾上腺素水平差异无显著意义。结论 冬眠药物可以削弱烧伤早期的神经内分泌反应对机体的损害。

    The effect of hibernative drugs on the serum level ofcorticosterone and catecholamine in the early stage of burned rabbit YuanKejian,Xu Weishi,Yang Huizhong,et al.Burn Center,Ruijin Hospital,Shanghai Second MedicalUniversity,Shanghai 200025

     【Abstract】 Objective To study whether the combination of early fluidreplacement with hibernative drugs can reduce the over reaction of neuro-endocrine systemin the early stage of burn.Methods Rabbits were subjected to burn of 15% TBSA. Hibernation cocktail was administered during the fluid replacement in thehibernation group,and only fluid replacement was given in control.The serum levels ofcorticosterone and catecholamine were measured at the 4th,8th,24th,48th and 72th hour ofpostburn.Results The serum levels of corticosterone and noradrenaline inhibernation group was significantly lower than that of control(P<0.05).There was nosignificant difference in the serum levels of adrenaline in two groups.Conclusion Hibernativedrugs might have some effects to reduce the injury due to over reaction of neuro-endocrine system in the early stage of burn.

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