王波涛 陈璧 胡大海 汤朝武 710032 西安，第四军医大学西京医院烧伤科 中华整形烧伤外科杂志 1999 0 15 2


    关键词：降钙素基因相关肽；肾上腺；免疫组化 期刊 zhzxsswkzz 0 论 著 fur -->


    

【摘要】 目的 探讨皮肤烫伤早期大鼠肾上腺内降钙素基因相关肽(CGRP)变化规律，为阐明烫伤后肾上腺内分泌功能改变的机理提供资料。方法 采用15%深Ⅱ度大鼠烫伤模型，以免疫组化方法分别检测烫伤后不同时相点肾上腺皮质、髓质CGRP免疫反应阳性神经和细胞分布密度的改变。结果 ①在肾上腺被膜，皮质，髓质均有含CGRP神经分布，其中髓质更为密集。在髓质可见含CGRP神经与CGRP免疫反应阳性细胞密切接触；②烫伤早期大鼠肾上腺皮质和髓质含CGRP神经的分布密度均下降，但髓质内CGRP免疫反应阳性细胞的分布密度上升。结论 降钙素基因相关肽可能是烫伤大鼠肾上腺功能改变的影响因素之一。

    The changes of calcitonin gene-related peptide (CGRP)-containing nerve fibers in adrenal gland of burned rats

WANG Botao, CHEN Bi, HU Dahai, et al.

    Department of Burn, Xijing Hospital of Fourth Military Medical University, Xi’an 710032

【 Abstract 】Objective To investigate the changes in calcitonin gene-related peptide(CGRP) within the adrenal glands medulla and cortex of the rat during early post burn period and the effect of CGRP on function of adrenal gland of burned rats.Methods The rats were randomly divided into two groups:control and burned. The distribution density of CGRP containing nerve fibers and cells in medulla of adrenal gland were determined at different timepoints post burn. Results ① The CGRP-containing nerve fibers were distributed in capsule, cortex and medulla. CGRP-containing nerve fibers were associated with CGRP immunoreactive cell in medulla of adrenal glands. ②Distribution density of CGRP-containing nerve fiber was decreased, but distribution density of CGRP-containing cells in medulla increased. ConclusionCGRP may affect function of the adrenal gland of burned rats.

     【 Key words】 Calcitonin gene-related peptide(CGRP) Adrenal gland Histochemistry

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