于勇 田惠民 盛志勇 施志国 王亚平 于燕 常国友 马诺山 100037 北京，解放军第三○四医院烧伤研究所 中华整形烧伤外科杂志 1998 0 14 2


    关键词：IgA；肠道细菌；细菌移位；脓毒症 期刊 zhzxsswkzz 0 肠道细菌/内毒素移位 fur -->


    

【摘要】 目的 探讨导致烧伤后肠源性感染的免疫学因素。方法 建立肠道细菌免疫球蛋白A(IgA)包被率的检测方法，对烫伤大鼠肠道细菌IgA包被率的变化和肠道细菌移位率的变化进行了动态观察。结果 40%体表面积烫伤后早期肠道细菌移位率明显升高，而后逐渐下降至伤前水平；各时相点肠道细菌的IgA包被率明显降低。结论 烧伤后肠道免疫屏障受到损伤，伤后肠道内IgA保护功能的减弱可促使肠道细菌移位，与烧伤后脓毒症的发生、发展有密切关系。

    A dynamic observation on change in coat rate ofintestinal bacteria by IgA in rats after thermal injury Yu Yong,TianHuimin,Sheng Zhiyong,et al.304th Hospital of People's Liberation Army,Beijing 100037

     【Abstract】 Objective To study the immunologic factors in thepathogenesis of gut\|dervied sepsis following burns.Methods The method ofcoat rate of intestinal bacteria by IgA was developed,and changes in coat rate ofintestinal bacteria by IgA and the incidence of bacterial translocation in rats afterthermal injury were pdetermined.Results After 40% TBSA thermal injury,anincrease in incidence of bacterial translocation and a decrease in coat rate of intestinalbacteria by IgA were detected.Conclusions The result indicated thatintestinal immuno\|barrier was damaged,and the protective function of IgA wasweakened,promoting bacterial translocation.It suggested that the decrease of coat rate ofintestinal bacteria by IgA might play an important role in the development of bacterialtranslocation and sepsis after thermal injury.

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