陈秀青 何成 赵小林 王成海 路长林 上海第二军医大学神经科学研究所，神经生物学教研室 200433 中华整形烧伤外科杂志 1999 0 15 4


    关键词：神经生长因子；睫状神经营养因子；一氧化氮；烧伤；脑损伤 期刊 zhzxsswkzz 0 论著 fur -->


    

【摘要】 目的 观察烫伤大鼠脑损伤时一氧化氮(NO)含量的变化及神经生长因子(NGF)、睫状神经营养因子(CNTF)分别对其不同脑区NO含量的影响，以初步探讨神经营养因子对烫伤大鼠脑组织的保护作用及其可能机制。方法 SD大鼠侧脑室埋管，麻醉后制成30%TBSAⅢ度烫伤。分成非烫伤组、烫伤组、烫伤+神经生长因子组、烫伤+睫状神经营养因子组。伤后3天，取不同脑区匀浆，测定脑组织中NO的含量。结果 烫伤后脑组织NO含量明显升高，给予NGF、CNTF后能明显降低不同脑区NO的含量。结论 烫伤后脑内NO升高可能是造成脑损伤的因素之一，NGF、CNTF对烫伤后脑组织的保护作用可能与其降低脑组织NO含量有关。

Effects of NGF and CNTF onNO level in brain of burn rats

CHEN Xiuqing,He Cheng,Zhao Xiaolin,et al.Department of Neurobiology,the Second Military MedicalUniversity,Shanghai,200433

【 Abstract 】 Objective To investigate the injurious effects of NO to the brainand protective effect of NGF and CNTF following burn injury in rats.Methods Following intubation of thelateral cerebroventricle,the rats were divided into four groups:shamburn,burn,burn+NGF,burn+CNTF.The contents of NO in various parts of brain in rats with 30%TBSA third degree scald were measured.Results The contents of NO were increased in burned rats.NGF andCNTF could lower the contents of NO.Conclusion The brain injury caused by burns may be associated withincrease of NO.The protective effect of NGF and CNTF on the brain of burn rats may berelated to lowering of NO.

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