葛凤 刘文彦 白波 史为清 刘平 葛凤 刘文彦 白波 史为清 272113 山东济宁医学院神经生理学研究室；刘平 第二附属医院 中华神经科杂志 1999 0 32 5


    关键词：β-内啡肽；神经降压素；水管周灰质；痛阈 期刊 zhsjkzz 0 论著摘要 fur -->


    

【摘要 】 目的 探讨大鼠中脑导水管周围灰质内神经降压素对β-内啡肽在痛行为反应中的影响。方法 以钾离子透入法引起大鼠甩尾反应的电流强度(mA)作为痛行为反应的指标，观察大鼠中脑导水管周围灰质内注入β-内啡肽、抗β-内啡肽血清、神经降压素和抗神经降压素血清对大鼠痛阈的影响。结果 中脑导水管周围灰质内注入β-内啡肽后，大鼠痛阈明显升高；注入抗β-内啡肽血清后，痛阈则明显降低。中脑导水管周围灰质内注入微量神经降压素后，可明显加强β-内啡肽的镇痛效应；注入抗神经降压素血清后，则明显削弱β-内啡肽的镇痛效应。结论 神经降压素参与中脑导水管周围灰质内注射β-内啡肽引起的镇痛效应。

Neurotensin injected into periagueductal gray could heighten effect of β-endorphin analgesia in rat

GE Feng^* , LIU Wenyan,BAI Bo, etal.

    *Departement of Physiology, Jining medical College,Jining 272113

【Abstract 】 Objective The effect of neurotensin(NT), anti-β-endorphin serum (AEPS) and β-endorphin (β-EP) injected into periaqueductal gray (PAG) on the pain threshold in rats was investigated in this study. Methods The potassium iontophoresis induced tail-flick was used to measure the pain threshold. Results β-EP which was injected into PAG produced analgesia effect in the rat. AEPS could weaken the pain threshold in PAG of rats.The micioinjection of NT in PAG could heighten effect of β-EP analgesia. Conclusion Our results indicated that β-EP could enhance the analgesia effect in PAG of rats,and this action of β-EP had closely related with the NT in PAG.

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