何明利 吴文孝 周培健 四川达川地区人民医院神经内科 635000 中华神经科杂志 1999 0 32 6


    关键词：脑缺血；血栓溶解疗法；尿激酶；疾病模型；动物 期刊 zhsjkzz 0 论著摘要 fur -->


    

【摘要 】 目的 对比性探讨尿激酶在犬大脑中动脉急性栓塞时动脉与静脉溶栓治疗的疗效。方法 建立犬自体血栓大脑中动脉栓塞(MCAO)模型，血管造影证实大脑中动脉(MCA)完全阻塞后3小时，经MCA注射尿激酶或静脉滴注尿激酶，监测各时相点的静脉凝血象变化，治疗后96小时进行病理学评定。结果 动脉溶栓组的平均MCA系统残留血栓重量极显著低于对照组和静脉溶栓组，动脉溶栓组的脑梗死容积亦小于其他两组。结论 犬急性缺血性脑卒中超早期选择性动脉溶栓治疗疗效可靠。

A compared study on efficacy of cerebral arterial and intra venous thrombolysis with urkinase for acute middle cerebral artery occlusion in dogs

HE Mingli, WU Wenxiao, ZHOU Peijian.

    Department of Neurology, Dachuan Prefectural Hospital, Dachuan 635000

【 Abstract 】 Objective To study the efficacy of cerebral arterial thombolysis and intravenous thombolysis with urokinase (UK) for acute cerebral ischemia. Methods To set up the model of middle cerebral artery occlusion (MCAO) with self-thombolus of dogs. UK was injected intra-arterially or intravenously when fully MCAO was confirmed by selected artery angiograph with intubating inta-arteria femoralis. To determined the dynamic changes of coagulative apparents at different times. Last, the ischemic cerebral tissues were assessed 96 hours after thombolysis. Results The mean MCA remaining thombolus weight in the intra-arterial thombolysis group was significantly decreased in comparison with the control group (t=19.75, P<0.001) and in the intravenous group (t=16.72, P<0.001), respectively and the cerebral infarction volumes in the intra-arterial thombolysis group were significantly reduced than that of another two groups. Conclusions The cerebral arterial thrombolysis with UK has high efficacy of thombolysis. So it can be considered to be one of the best ways to treat acute ischemic stroke.

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