关键词：脉冲振荡法；阻力；电抗
【摘要】 目的
初步探讨脉冲振荡法(IOS)的测定指标判断呼吸疾病气道阻力和肺顺应性的临床规律和意义。方法 测定、分析40名健康人、50例慢性阻塞性肺疾病(COPD)患者和60例胸腔积液患者的各项IOS指标(在5～35 Hz时)。同时以传统方法测定一秒钟用力呼气容积占用力肺活量比值(FEV1 /FVC)和最大呼气流量-容积曲线(MEFV曲线)。对IOS主要结果作t检验。结果 与健康组比较，COPD组周边及部分中心阻力明显增高，共振频率增高，周边电抗下降(P<0.01)；频谱图中R线呈下凹曲线，呼气末阻力增加和电抗下降。FEV1 /FVC<50%，MEFV曲线为严重阻塞形态。胸腔积液组均在低频段出现吸气末阻力增高和电抗下降；FEV1 /FVC接近正常，MEFV曲线仅半数为限制性功能障碍形态。结论 IOS能够较好反映气道阻力和肺顺应性的变化，可能有一定的应用前景。Clinical application of impulse oscillometry
LI Changjian , ZHAO Lianyun. The Pulmonary Function Laboratory, Chest Hospital, Tianjin 300051
【Abstract】 Objective To discuss the clinical significance of impulse oscillometry(IOS) to determine the resistance of large and small airways and the compliance of lung. Methods The IOS indices of 40 normal cases, 50 cases of chronic obstructive pulmonary diseases (COPD) and 60 cases of pleural effusion were determined at 5～35 Hz. Their FEV1 /FVC and maximal expiratory flow-volume curve (MEFV curve) were measured in conventional method at the same time Results Compared with normal cases, the peripheral resistance of the 50 patients with COPD rose obviously and the central airway resistance rose in some of them, the resonance frequency increased, but the peripheral reactance descended at the same time (P<0.01). Resistance curve show markedly nonlinear decreasing course with increasing frequency. The resistance increased and the reactance descended in end-expiration. FEV1 /FVC<50% , MEFV curve showed severe obstructive shape. 60 patients with pleural effusion were found the resistance increasing and reactance descending to negative values in end-inpiration at low frequencies (inverse values relation at low frequencies). FEV1 /FVC were nearly normal , MEFV curve showed restrictive dysfunction shape only in half of them. Conclusions IOS can reflect variation of airway resistance and lung compliance. The future development of IOS could be prosperous.
【Key words】 Impulse oscillometry Resistance Reactance
脉冲振荡法(IOS)是强迫振荡技术(FOT)用于肺功能检测的一种类型 ......
您现在查看是摘要页，全文长 11460 字符。