刘好文 李娜 田成林 张洪英 刘俊艳 李育臣 王树义 王建茹 高洪泉 050051 石家庄，河北医科大学第三医院神经内科 中华神经科杂志 1998 0 31 4


    关键词：痉挛；面肌；肉毒毒素类；核磁血管成像 期刊 zhsjkzz 0 *论著* fur -->


    

【摘要】 目的 探讨面肌痉挛的病因，评估A型肉毒毒素治疗面肌痉挛的疗效。方法 对118例病人进行面部肌肉多点注射A型肉毒毒素治疗，对治疗前后的病情分级进行对比，并随机抽取36例做肌电图，12例做核磁共振血管成像(MRA)检查。结果 A型肉毒毒素有效率为94%，半年复发率为87%。肌电图全部显示自发性动作电位。12例MRA中，11例检出有椎动脉、小脑后下动脉、小脑前下动脉的变异，并造成对面神经的压迫。结论 部分面肌痉挛的病因为血管压迫。尽管A型肉毒毒素的疗效多不超过半年，但仍不失为一种简单有效的治疗方法。

    Clinical observation of therapeutic effects botulin A on 118hemifacial spasm patients Liu Haowen, Li Na, Tian Chenglin, et al. Department of Neurology, the Third Hospital of Hebei Medical University,Shijiazhuang 050051

    【Abstract】 Objective To explore thecause of hemifacial spasm (HFS) and evaluate the therapeutic efficacy of botulin A.Methods 118 HFS patients were studied on therapeuticefficacy of multifocal facial injections with botulin A. Symptomatic alleviations afterthe injection were graded in comparison with the symptoms at the pretreatment stage.Electromyography (EMG) was performed in 36 patients and magnetic resonance angiography (MRA) in 12 patients at random. Results Followingthe treatment, 94% of the patients were relieved of symptoms, but 87% of the patientsrelapsed about half a year later. EMG was performed in 36 patients with the presence ofspontaneous action potentials. MRA was performed in 12 patients, demonstrating theaberrances of the vertebral artery, the posterior inferior cerebellar artery or theanterior inferior cerebellar artery, with certain compressions of the involved facialnerves in 11 cases. Conclusions The vascularcompression of the involved facial nerves might be identified as the more likely cause of HFS. Therapeutic efficacy of botulin A usually lasted no longer than six months.Substantially, the botulin A injections could serve as a kind of easy and usefulsymptomatic treatment.

     ......