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关键词：淋巴瘤；恶性、原发性；；活组织检查；脑
【摘要】 目的 回顾性分析13例中枢神经系统原发性恶性淋巴瘤(CPML)患者的临床资料。方法 对本病的临床、实验室、影像学及病理学检查进行分析。结果 发现CPML患者的临床表现复杂,颅高压和神经系统缺损的症状和体征为主要表现;脑脊液中蛋白定量增高，肿瘤可呈单发或多发,以额叶和颞叶多见。CPML的病理形态学与身体其他部位的恶性淋巴瘤颇相似,绝大多数起源于B淋巴细胞。结论 CPML的临床或影像学均缺乏特异性表现,早期诊断十分困难,脑活组织病理检查是确诊本病的唯一手段。
A retrospective analysis of 13 cases central nervous systemprimary malignant lymphoma Zhao Xiping , Ye Min , Zhang Ping, et al. Department of Neurology, Affiliated Brain Hospital, Nanjing Medical University, Nanjing 210029
【Abstract】 Objective To analyse 13 casesof central nervous system primary malignant lymphoma(CPML). Method The clinical, laboratory, neuroradiological and pathological dataof 13 cases of CPML were analysed. Results Thecommon clinical findings of CPML consisted of increased intracranial pressure, seizures,impaired cortical function and focal neurologic deficits. Studies of CSF revealed proteinelevations in excess of 1.0 g/L in all of the patients who had lumbar punctures.Neuroradiological examinations with CT and MRI both showed solitary or multipleintracranial masses of tumor located particularly in the frontal and temporal lobes.Pathological examination showed that lymphomas arising in CNS were morphologicaly similarto those originating elsewhere in the other patients′ bodies. The greater majority of CPML had been of B-cell origin.Conclusion The patients of CPML usually did notshow characteristic clinical manifestations or findings in imaging scanning unless therewere specific complications. A new approach in the diagnosis of this disease with the useof brain biopsy pathological examination might be the more reliable method to confirm thisdisorder.
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