王建春 毛宝龄 陈正堂 孙耕耘 陈维中 李淑平 400037 重庆，第三军医大学新桥医院呼吸内科研究所 中华结核和呼吸感染 1999 0 22 6


    关键词：急性肺损伤；氧合酶-2；氧合酶抑制剂；列腺素 期刊 zhjhhhxgr 0 述评 fur -->


    

摘要 目的 探讨急性肺损伤(ALI)肺组织环氧合酶-2(COX-2)mRNA表达的变化以及选择性COX-2抑制剂Meloxicam的干预作用。方法 脂多糖(LPS)诱发大鼠ALI模型，采用逆转录-聚合酶链反应，检测其肺组织COX-2 mRNA表达并观察其前列腺素(PGs)、动脉血氧分压(PaO₂ )及病理变化。结果 静息状态的大鼠肺组织表达少量的COX-2 mRNA，在ALI大鼠肺组织COX-2 mRNA大量表达，Meloxicam可减轻肺组织病理损伤、降低PGs产量，使PaO₂ 下降程度减轻。结论 COX-2是ALI时PGs升高的主要同工酶，Meloxicam可抑制COX-2活性，对ALI具有一定的防治作用。

    

The effect of cyclooxygenase-2 inhibitor on acute lung injury

WANG Jianchun, MAO Baoling, CHEN Zhengtang, et al.

    Institute of Respiratory Medicine ,Xinqiao Hospital,Third Military Medical University, Chongqing 400037

Abstract Objective To investigate changes of cyclooxygenase-2 (COX-2) mRNA expression and intervention effect of selective cyclooxygenase-2 inhibitor Meloxicam on acute lung injury (ALI). Methods We measured COX-2 mRNA expression by reverse-transcription polymerase chain reaction in rat lung with ALI induced by lipopolysaccharide, and observed changes of prostaglandins (PGs)、PaO2 and histopathology. Results Resting rat lung expressed a little COX-2 mRNA ; expression of cyclooxygenase-2 mRNA was up-regulated significantly in the lung after rats were injured by LPS. Selective COX-2 inhibitor Meloxicam alleviated histopathologic damage in the lung, inhibited production of PGs and attenuated PaO₂ decline. Conclusions COX-2 is a main isoform responsible for enhancing PGs production during ALI. Meloxicam can inhibit activity of COX-2 and may be useful in the treatment of ALI.

    Key words Acute lung injury Cyclooxygenase-2 Cyclooxygenase inhibitor Prostaglandins

环氧合酶(COX)是前列腺素(PGs)合成过程中的一个重要限速酶 ......

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