【摘要 】 目的 对新型植生克雷伯菌致院内获得性肺炎临床流行病学与生物学特性进行研究。方法 从住院肺科患者的呼吸道标本分出的9株植生克雷伯菌，采用生物学、血清学与动物学试验方法鉴定，并对该菌所致院内获得性肺炎进行临床流行病学调查。结果 9株植生克雷伯菌具有克雷伯菌属生物学共性，但与其他克雷伯菌生化特性有别。血清学与动物试验证明，分离菌株为致患者呼吸道感染的临床病原株。药敏试验结果：全部菌株对青霉素、氨苄青霉素与羧苄青霉素耐药；对红霉素、四环素、氯霉素多不敏感；对第二、三代头孢菌素敏感率较高；对诺氟沙星、环丙沙星、亚胺培南无耐药菌株。此外，对该菌致院内获得性肺炎临床表现、致病特点、治疗措施进行了讨论。结论 新型植生克雷伯菌检出，为国内克雷伯菌增加了新的菌型；为该菌的临床、治疗提供了资料。

Studies on the biological andclinical characteristics of acquired pneumonia caused by K.planticola Luo Guangrong, Tan Xianghu, Luo Hong, et al. The secondhospital of Jing Zhou, Jing Zhou 434000

【Abstracts 】 Objective Toinvestigate the characteristics of biological, and clinical epidemiology of acquiredpneumonia caused by a new type of Klebsiella, K. planticola. Method 9 strains of K. planticola were isolated from respiratory samplesof patients, in vitro, biological and serologic identification were done, in vivo,infected animal models were also evaluated. Clinical epidemiolgical inquiries were alsoperformed. Result 9 strains′ biological features were different from those of the other Klebsiella. The 9 patients′ ages were over forty andthe primary disease was the third type tuberculosis of lungs. Using of antituberculosisdrugs for long term as well as penicillines might be the predisposing factors,corticosteroids were used in 3 of the 9 patients, Combined infection with other pathogensin addition to K. planticola occurred in 8 patients, in 7/8, Candida albicans wasidentified. Drug sensitive tests show that all of them were resistent to penicillines andsensitive to the second and third generation cephalosporins. Conclusion The new strain of Klebsiella was studied and this information willbe useful for diagnosing and treating K. platicola.

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