【摘要 】 目的 探讨以HR为主不同疗程化疗方案对菌阳尘肺结核的近远期疗效。方法 将79例菌阳病例分为9月组(M9：2SHRZ/7HRE)、12月组(M12:2SHRZ/10HRE)、18月组(M18:2SHRZ/10HRE/6HR)，分别采用不同方案治疗。疗效考核以痰菌为主要依据。满疗程随访5～8年。结果 M9、M12、M18组满疗程痰菌阴转率分别为83%、96%、95%，随访期间痰菌复阳率分别为41%、4%、5%，其中随访1～4年痰菌复阳率分别为6%、8%、2%、2%，第5～8年无复阳病例。结论 12月方案(2SHRZ/10HRE)对复治菌阳尘肺结核有效；随访时间以4～5年为宜。

Efficacy of regimens containingINH,RFP with varied chemotherapy courses on retreated culture positive pneumoconio-tuberculosis Jiang Wenzhong, Chen Huaihua, Gao Jinsong. Huaibei Mineral Occupational Hospital for Treatmentand Prevention, Huaibei, Anhui 235000

【Abstract 】 Objective Toevaluate the short and long-term effects of regimens containing INH、RFP with varied chemotherapy courses on culture-positive pneumoconio-tuberculosis. Method 79patients with culture-positive pneumoconio-tuberculosis were divided into three groupsaccording to chemotherapy duration: 9-months group(M9:2SHRZ/7HRE) 28 cases,12-monthgroup(2SHRZ/10HRE) 25 cases, 18-month group(M18:2SHRZ/10HRE/6HR)26cases.Evaluating theefficacy of regimens depended predominantly on sputum bacteriological conversion, and thepatients who completed the regimens were followed up for 5～8 years. Result Sputum negative conversion rates of three groups at the end ofchemotherapy were 83%, 96%, 95%,and their recurrent rates in follow-up period 41%, 4% and5% respectively.Of all patients who completed the regimens bacteriological relapse ratesfrom the first to fourth year are 6%, 8%, 2%, 2% in the follow-up period.There was nobacteriological relapse from fifth to eighth year. Conclusion It is effective for SHRZ/HRE combination with 12-months course toretreated tubercle bacillus positive pneumoconio-tuberculosis, and it is appropriate forsuch patients to be followed up for 4～5 years.

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